| Title |
Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium
|
|---|---|
| Published in |
European Journal of Epidemiology, October 2017
|
| DOI | 10.1007/s10654-017-0320-5 |
| Pubmed ID | |
| Authors |
Lori B. Chibnik, Frank J. Wolters, Kristoffer Bäckman, Alexa Beiser, Claudine Berr, Joshua C. Bis, Eric Boerwinkle, Daniel Bos, Carol Brayne, Jean-Francois Dartigues, Sirwan K. L. Darweesh, Stephanie Debette, Kendra L. Davis-Plourde, Carole Dufouil, Myriam Fornage, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M. Arfan Ikram, M. Kamran Ikram, Silke Kern, Lewis H. Kuller, Lenore Launer, Oscar L. Lopez, Fiona Matthews, Osorio Meirelles, Thomas Mosley, Alison Ower, Bruce M. Psaty, Claudia L. Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom C. M. Stephan, Christophe Tzourio, Reem Waziry, Mei Mei Wong, Anna Zettergren, Albert Hofman |
| Abstract |
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 69 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 17% |
| Student > Ph. D. Student | 11 | 16% |
| Student > Bachelor | 8 | 12% |
| Researcher | 8 | 12% |
| Student > Doctoral Student | 6 | 9% |
| Other | 8 | 12% |
| Unknown | 16 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 18 | 26% |
| Nursing and Health Professions | 7 | 10% |
| Neuroscience | 4 | 6% |
| Psychology | 4 | 6% |
| Mathematics | 2 | 3% |
| Other | 12 | 17% |
| Unknown | 22 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2020.
All research outputs
#1,875,236
of 23,577,761 outputs
Outputs from European Journal of Epidemiology
#268
of 1,669 outputs
Outputs of similar age
#39,089
of 329,238 outputs
Outputs of similar age from European Journal of Epidemiology
#10
of 27 outputs
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