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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A drug pocket at the lipid bilayer–potassium channel interface
|
|---|---|
| Published in |
Science Advances, October 2017
|
| DOI | 10.1126/sciadv.1701099 |
| Pubmed ID | |
| Authors |
Nina E. Ottosson, Malin Silverå Ejneby, Xiongyu Wu, Samira Yazdi, Peter Konradsson, Erik Lindahl, Fredrik Elinder |
| Abstract |
Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthesized and electrophysiologically tested 125 derivatives, analogs, and related compounds to dehydroabietic acid. Functional data in combination with docking and molecular dynamics simulations mapped a binding site for small-molecule compounds at the interface between the lipid bilayer and the transmembrane segments S3 and S4 of the voltage-sensor domain. This fundamentally new binding site for small-molecule compounds paves the way for the design of new types of drugs against diseases caused by altered excitability. |
X Demographics
The data shown below were collected from the profiles of 23 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 22% |
| United States | 4 | 17% |
| France | 3 | 13% |
| Belgium | 2 | 9% |
| Japan | 1 | 4% |
| Australia | 1 | 4% |
| Switzerland | 1 | 4% |
| Unknown | 6 | 26% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 52% |
| Scientists | 10 | 43% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 23% |
| Student > Ph. D. Student | 8 | 20% |
| Student > Bachelor | 6 | 15% |
| Student > Doctoral Student | 5 | 13% |
| Student > Master | 3 | 8% |
| Other | 6 | 15% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 23% |
| Agricultural and Biological Sciences | 6 | 15% |
| Neuroscience | 5 | 13% |
| Chemistry | 5 | 13% |
| Engineering | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 5 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2018.
All research outputs
#877,962
of 25,382,440 outputs
Outputs from Science Advances
#5,106
of 12,215 outputs
Outputs of similar age
#18,490
of 338,212 outputs
Outputs of similar age from Science Advances
#99
of 197 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,215 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 120.3. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,212 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 197 others from the same source and published within six weeks on either side of this one. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.