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Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

Overview of attention for article published in New England Journal of Medicine, October 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

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Title
Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery
Published in
New England Journal of Medicine, October 2017
DOI 10.1056/nejmoa1703784
Pubmed ID
Authors

Ingmar Blumcke, Roberto Spreafico, Gerrit Haaker, Roland Coras, Katja Kobow, Christian G Bien, Margarete Pfäfflin, Christian Elger, Guido Widman, Johannes Schramm, Albert Becker, Kees P Braun, Frans Leijten, Johannes C Baayen, Eleonora Aronica, Francine Chassoux, Hajo Hamer, Hermann Stefan, Karl Rössler, Maria Thom, Matthew C Walker, Sanjay M Sisodiya, John S Duncan, Andrew W McEvoy, Tom Pieper, Hans Holthausen, Manfred Kudernatsch, H Joachim Meencke, Philippe Kahane, Andreas Schulze-Bonhage, Josef Zentner, Dieter H Heiland, Horst Urbach, Bernhard J Steinhoff, Thomas Bast, Laura Tassi, Giorgio Lo Russo, Cigdem Özkara, Buge Oz, Pavel Krsek, Silke Vogelgesang, Uwe Runge, Holger Lerche, Yvonne Weber, Mrinalini Honavar, José Pimentel, Alexis Arzimanoglou, Adriana Ulate-Campos, Soheyl Noachtar, Elisabeth Hartl, Olaf Schijns, Renzo Guerrini, Carmen Barba, Thomas S Jacques, J Helen Cross, Martha Feucht, Angelika Mühlebner, Thomas Grunwald, Eugen Trinka, Peter A Winkler, Antonio Gil-Nagel, Rafael Toledano Delgado, Thomas Mayer, Martin Lutz, Basilios Zountsas, Kyriakos Garganis, Felix Rosenow, Anke Hermsen, Tim J von Oertzen, Thomas L Diepgen, Giuliano Avanzini

Abstract

Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 578 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 578 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 86 15%
Student > Ph. D. Student 68 12%
Other 53 9%
Student > Master 46 8%
Student > Bachelor 46 8%
Other 129 22%
Unknown 150 26%
Readers by discipline Count As %
Medicine and Dentistry 175 30%
Neuroscience 102 18%
Biochemistry, Genetics and Molecular Biology 18 3%
Agricultural and Biological Sciences 14 2%
Pharmacology, Toxicology and Pharmaceutical Science 10 2%
Other 60 10%
Unknown 199 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 115. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2023.
All research outputs
#366,337
of 25,523,622 outputs
Outputs from New England Journal of Medicine
#5,535
of 32,545 outputs
Outputs of similar age
#7,716
of 338,575 outputs
Outputs of similar age from New England Journal of Medicine
#122
of 271 outputs
Altmetric has tracked 25,523,622 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,545 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 122.4. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,575 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 271 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.