| Title |
Molecular mechanisms of α-synuclein and GBA1 in Parkinson’s disease
|
|---|---|
| Published in |
Cell and Tissue Research, October 2017
|
| DOI | 10.1007/s00441-017-2704-y |
| Pubmed ID | |
| Authors |
Iva Stojkovska, Dimitri Krainc, Joseph R. Mazzulli |
| Abstract |
Parkinson's disease (PD) is a neurodegenerative movement disorder characterized pathologically by the presence of Lewy bodies comprised of insoluble alpha (α)-synuclein. Pathological, clinical and genetic studies demonstrate that mutations in the GBA1 gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase) that is deficient in Gaucher's disease, are important risk factors for the development of PD. The molecular mechanism for the association between these two diseases is not completely understood. We discuss several possible mechanisms that may lead to GBA1-related neuronal death and α-synuclein accumulation including disruptions in lipid metabolism, protein trafficking and impaired protein quality control mechanisms. Elucidating the mechanism between GCase and α-synuclein may provide insight into potential therapeutic pathways for PD and related synucleinopathies. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 150 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 15% |
| Student > Bachelor | 22 | 15% |
| Student > Master | 21 | 14% |
| Student > Ph. D. Student | 17 | 11% |
| Student > Doctoral Student | 7 | 5% |
| Other | 17 | 11% |
| Unknown | 44 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 33 | 22% |
| Neuroscience | 24 | 16% |
| Agricultural and Biological Sciences | 12 | 8% |
| Medicine and Dentistry | 12 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Other | 14 | 9% |
| Unknown | 50 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2024.
All research outputs
#2,057,017
of 25,157,832 outputs
Outputs from Cell and Tissue Research
#33
of 2,229 outputs
Outputs of similar age
#39,743
of 334,240 outputs
Outputs of similar age from Cell and Tissue Research
#1
of 47 outputs
Altmetric has tracked 25,157,832 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,229 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.