Title |
Recent developments in therapeutic protein expression technologies in plants
|
---|---|
Published in |
Biotechnology Techniques, October 2014
|
DOI | 10.1007/s10529-014-1699-7 |
Pubmed ID | |
Authors |
Shah Fahad, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Muhammad Mahmood Ahmed, Yu Cai Liao, Muhammad Tahir Waheed, Muhammad Sameeullah, Darkhshan, Saddam Hussain, Shah Saud, Shah Hassan, Amanullah Jan, Mohammad Tariq Jan, Chao Wu, Ma Xiao Chun, Jianliang Huang |
Abstract |
Infectious diseases and cancers are some of the commonest causes of deaths throughout the world. The previous two decades have witnessed a combined endeavor across various biological sciences to address this issue in novel ways. The advent of recombinant DNA technologies has provided the tools for producing recombinant proteins that can be used as therapeutic agents. A number of expression systems have been developed for the production of pharmaceutical products. Recently, advances have been made using plants as bioreactors to produce therapeutic proteins directed against infectious diseases and cancers. This review highlights the recent progress in therapeutic protein expression in plants (stable and transient), the factors affecting heterologous protein expression, vector systems and recent developments in existing technologies and steps towards the industrial production of plant-made vaccines, antibodies, and biopharmaceuticals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 50% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 122 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 19% |
Researcher | 20 | 16% |
Student > Master | 20 | 16% |
Student > Bachelor | 17 | 14% |
Student > Doctoral Student | 5 | 4% |
Other | 15 | 12% |
Unknown | 23 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 39% |
Biochemistry, Genetics and Molecular Biology | 28 | 23% |
Engineering | 5 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Chemical Engineering | 3 | 2% |
Other | 8 | 6% |
Unknown | 28 | 23% |