| Title |
Perceived cognitive impairment in people with colorectal cancer who do and do not receive chemotherapy
|
|---|---|
| Published in |
Journal of Cancer Survivorship, October 2017
|
| DOI | 10.1007/s11764-017-0656-6 |
| Pubmed ID | |
| Authors |
Haryana M. Dhillon, Ian F. Tannock, Gregory R. Pond, Corrinne Renton, Sean B. Rourke, Janette L. Vardy |
| Abstract |
Cognitive symptoms are common after cancer, but poorly associated with neuropsychological results. We previously reported colorectal cancer (CRC) patients had more cognitive impairment than controls. Here, we explore relationships between cognitive symptoms and neuropsychological domains. Subjects with CRC (N = 362) and 72 healthy controls completed neuropsychological assessments and Functional Assessment of Cancer Therapy-Cognition (FACT-COG) at baseline (pre-chemotherapy) and 6, 12, and 24 months. Associations between neuropsychological and FACT-COG scores were explored: perceived cognitive impairment (PCI), perceived cognitive ability (PCA), impact of PCI on quality of life (CogQOL). Of 362 CRC subjects, 289 had loco-regional disease and 173 received chemotherapy (CTh+). At baseline, groups did not differ on total FACT-COG, PCI, or PCA scores. All scores, except PCA, were worse at 6 months in CTh+. CRC patients not receiving chemotherapy did not differ from controls on FACT-COG domains. PCA associated weakly (r = 0.28-0.34) with attention/executive function, visual memory, and global deficit score. There was no association between PCI and neuropsychological domains. Fatigue, anxiety/depression, and poorer quality of life were associated with PCI and CogQOL (r = 0.44-0.51) in CRC patients. No association was seen between total FACT-COG or PCI, and neuropsychological domains. A weak-moderate association was found between PCA and attention/executive function and visual memory. The study was registered with clinicaltrials.gov (trial registration: NCT00188331). Cognitive symptoms are associated with fatigue, anxiety/depression, and poorer quality of life, and do not appear to be related to actual cognitive performance. Rates were lower than that reported in breast cancer survivors. Cognitive symptoms were greatest in those who received chemotherapy, with no significant difference between the non-chemotherapy survivors and healthy controls. |
X Demographics
The data shown below were collected from the profiles of 22 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 5 | 23% |
| Netherlands | 3 | 14% |
| United Kingdom | 2 | 9% |
| United States | 2 | 9% |
| Switzerland | 1 | 5% |
| Comoros | 1 | 5% |
| Brazil | 1 | 5% |
| Unknown | 7 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 55% |
| Scientists | 8 | 36% |
| Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 110 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 13% |
| Student > Ph. D. Student | 13 | 12% |
| Student > Bachelor | 12 | 11% |
| Student > Master | 11 | 10% |
| Student > Postgraduate | 5 | 5% |
| Other | 16 | 15% |
| Unknown | 39 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 22 | 20% |
| Medicine and Dentistry | 15 | 14% |
| Neuroscience | 8 | 7% |
| Nursing and Health Professions | 7 | 6% |
| Unspecified | 5 | 5% |
| Other | 7 | 6% |
| Unknown | 46 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 June 2019.
All research outputs
#2,682,113
of 25,205,864 outputs
Outputs from Journal of Cancer Survivorship
#189
of 1,144 outputs
Outputs of similar age
#49,972
of 335,056 outputs
Outputs of similar age from Journal of Cancer Survivorship
#6
of 20 outputs
Altmetric has tracked 25,205,864 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,144 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done well, scoring higher than 83% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.