| Title |
Antibiotic resistance of pathogenic Acinetobacter species and emerging combination therapy
|
|---|---|
| Published in |
Journal of Microbiology, October 2017
|
| DOI | 10.1007/s12275-017-7288-4 |
| Pubmed ID | |
| Authors |
Bora Shin, Woojun Park |
| Abstract |
The increasing antibiotic resistance of Acinetobacter species in both natural and hospital environments has become a serious problem worldwide in recent decades. Because of both intrinsic and acquired antimicrobial resistance (AMR) against last-resort antibiotics such as carbapenems, novel therapeutics are urgently required to treat Acinetobacter-associated infectious diseases. Among the many pathogenic Acinetobacter species, A. baumannii has been reported to be resistant to all classes of antibiotics and contains many AMR genes, such as bla ADC (Acinetobacter-derived cephalosporinase). The AMR of pathogenic Acinetobacter species is the result of several different mechanisms, including active efflux pumps, mutations in antibiotic targets, antibiotic modification, and low antibiotic membrane permeability. To overcome the limitations of existing drugs, combination theraphy that can increase the activity of antibiotics should be considered in the treatment of Acinetobacter infections. Understanding the molecular mechanisms behind Acinetobacter AMR resistance will provide vital information for drug development and therapeutic strategies using combination treatment. Here, we summarize the classic mechanisms of Acinetobacter AMR, along with newly-discovered genetic AMR factors and currently available antimicrobial adjuvants that can enhance drug efficacy in the treatment of A. baumannii infections. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 113 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 18% |
| Student > Bachelor | 17 | 15% |
| Student > Master | 16 | 14% |
| Researcher | 13 | 12% |
| Student > Doctoral Student | 4 | 4% |
| Other | 9 | 8% |
| Unknown | 34 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 19 | 17% |
| Biochemistry, Genetics and Molecular Biology | 16 | 14% |
| Medicine and Dentistry | 15 | 13% |
| Agricultural and Biological Sciences | 12 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 7% |
| Other | 8 | 7% |
| Unknown | 35 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2017.
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#19,495,804
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Outputs from Journal of Microbiology
#564
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#256,917
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Outputs of similar age from Journal of Microbiology
#15
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