| Title |
Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet
|
|---|---|
| Published in |
European Journal of Nutrition, October 2017
|
| DOI | 10.1007/s00394-017-1558-0 |
| Pubmed ID | |
| Authors |
Caroline Blomquist, Elin Chorell, Mats Ryberg, Caroline Mellberg, Evelina Worrsjö, Elena Makoveichuk, Christel Larsson, Bernt Lindahl, Gunilla Olivecrona, Tommy Olsson |
| Abstract |
We studied effects of diet-induced postmenopausal weight loss on gene expression and activity of proteins involved in lipogenesis and lipolysis in adipose tissue. Fifty-eight postmenopausal women with overweight (BMI 32.5 ± 5.5) were randomized to eat an ad libitum Paleolithic-type diet (PD) aiming for a high intake of protein and unsaturated fatty acids or a prudent control diet (CD) for 24 months. Anthropometry, plasma adipokines, gene expression of proteins involved in fat metabolism in subcutaneous adipose tissue (SAT) and lipoprotein lipase (LPL) activity and mass in SAT were measured at baseline and after 6 months. LPL mass and activity were also measured after 24 months. The PD led to improved insulin sensitivity (P < 0.01) and decreased circulating triglycerides (P < 0.001), lipogenesis-related factors, including LPL mRNA (P < 0.05), mass (P < 0.01), and activity (P < 0.001); as well as gene expressions of CD36 (P < 0.05), fatty acid synthase, FAS (P < 0.001) and diglyceride acyltransferase 2, DGAT2 (P < 0.001). The LPL activity (P < 0.05) and gene expression of DGAT2 (P < 0.05) and FAS (P < 0.05) were significantly lowered in the PD group versus the CD group at 6 months and the LPL activity (P < 0.05) remained significantly lowered in the PD group compared to the CD group at 24 months. Compared to the CD, the PD led to a more pronounced reduction of lipogenesis-promoting factors in SAT among postmenopausal women with overweight. This could have mediated the favorable metabolic effects of the PD on triglyceride levels and insulin sensitivity. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 133 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 24 | 18% |
| Student > Master | 17 | 13% |
| Student > Postgraduate | 8 | 6% |
| Student > Ph. D. Student | 8 | 6% |
| Researcher | 6 | 5% |
| Other | 18 | 14% |
| Unknown | 52 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 15% |
| Nursing and Health Professions | 20 | 15% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Agricultural and Biological Sciences | 8 | 6% |
| Sports and Recreations | 3 | 2% |
| Other | 14 | 11% |
| Unknown | 59 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2021.
All research outputs
#13,505,232
of 24,132,691 outputs
Outputs from European Journal of Nutrition
#1,472
of 2,502 outputs
Outputs of similar age
#153,211
of 331,788 outputs
Outputs of similar age from European Journal of Nutrition
#31
of 45 outputs
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