Title |
Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response
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Published in |
Applied and Environmental Microbiology, November 2013
|
DOI | 10.1128/aem.03313-13 |
Pubmed ID | |
Authors |
Francesca Turroni, Valentina Taverniti, Patricia Ruas-Madiedo, Sabrina Duranti, Simone Guglielmetti, Gabriele Andrea Lugli, Laura Gioiosa, Paola Palanza, Abelardo Margolles, Douwe van Sinderen, Marco Ventura |
Abstract |
Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 24 | 33% |
Student > Master | 7 | 10% |
Student > Bachelor | 7 | 10% |
Student > Ph. D. Student | 6 | 8% |
Student > Doctoral Student | 4 | 5% |
Other | 14 | 19% |
Unknown | 11 | 15% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 17 | 23% |
Agricultural and Biological Sciences | 16 | 22% |
Medicine and Dentistry | 9 | 12% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Environmental Science | 2 | 3% |
Other | 4 | 5% |
Unknown | 18 | 25% |