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X Demographics
Mendeley readers
Attention Score in Context
| Title |
In Vivo Application of Tissue-Engineered Veins Using Autologous Peripheral Whole Blood: A Proof of Concept Study
|
|---|---|
| Published in |
EBioMedicine, September 2014
|
| DOI | 10.1016/j.ebiom.2014.09.001 |
| Pubmed ID | |
| Authors |
Michael Olausson, Vijay Kumar Kuna, Galyna Travnikova, Henrik Bäckdahl, Pradeep B. Patil, Robert Saalman, Helena Borg, Anders Jeppsson, Suchitra Sumitran-Holgersson |
| Abstract |
Vascular diseases are increasing health problems affecting > 25 million individuals in westernized societies. Such patients could benefit from transplantation of tissue-engineered vascular grafts using autologous cells. One challenge that has limited this development is the need for cell isolation, and risks associated with ex vivo expanded stem cells. Here we demonstrate a novel approach to generate transplantable vascular grafts using decellularized allogeneic vascular scaffolds, repopulated with peripheral whole blood (PWB) in vitro in a bioreactor. Circulating, VEGFR-2 +/CD45 + and a smaller fraction of VEGFR-2 +/CD14 + cells contributed to repopulation of the graft. SEM micrographs showed flat cells on the luminal surface of the grafts consistent with endothelial cells. For clinical validation, two autologous PWB tissue-engineered vein conduits were prepared and successfully used for by-pass procedures in two pediatric patients. These results provide a proof of principle for the generation of transplantable vascular grafts using a simple autologous blood sample, making it clinically feasible globally. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 5 | 29% |
| Sweden | 2 | 12% |
| United Kingdom | 2 | 12% |
| India | 1 | 6% |
| United States | 1 | 6% |
| Unknown | 6 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 76% |
| Practitioners (doctors, other healthcare professionals) | 2 | 12% |
| Scientists | 1 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Czechia | 1 | 1% |
| United Kingdom | 1 | 1% |
| Russia | 1 | 1% |
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 78 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 19% |
| Student > Ph. D. Student | 14 | 17% |
| Student > Master | 13 | 15% |
| Student > Bachelor | 9 | 11% |
| Professor > Associate Professor | 4 | 5% |
| Other | 11 | 13% |
| Unknown | 17 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 21% |
| Medicine and Dentistry | 13 | 15% |
| Engineering | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 8% |
| Materials Science | 4 | 5% |
| Other | 5 | 6% |
| Unknown | 26 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 144. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 October 2022.
All research outputs
#286,999
of 25,374,917 outputs
Outputs from EBioMedicine
#156
of 4,009 outputs
Outputs of similar age
#2,658
of 262,429 outputs
Outputs of similar age from EBioMedicine
#1
of 21 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,009 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 32.0. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,429 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.