| Title |
Primary age-related tauopathy (PART): a common pathology associated with human aging
|
|---|---|
| Published in |
Acta Neuropathologica, October 2014
|
| DOI | 10.1007/s00401-014-1349-0 |
| Pubmed ID | |
| Authors |
John F. Crary, John Q. Trojanowski, Julie A. Schneider, Jose F. Abisambra, Erin L. Abner, Irina Alafuzoff, Steven E. Arnold, Johannes Attems, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Dennis W. Dickson, Marla Gearing, Lea T. Grinberg, Patrick R. Hof, Bradley T. Hyman, Kurt Jellinger, Gregory A. Jicha, Gabor G. Kovacs, David S. Knopman, Julia Kofler, Walter A. Kukull, Ian R. Mackenzie, Eliezer Masliah, Ann McKee, Thomas J. Montine, Melissa E. Murray, Janna H. Neltner, Ismael Santa-Maria, William W. Seeley, Alberto Serrano-Pozo, Michael L. Shelanski, Thor Stein, Masaki Takao, Dietmar R. Thal, Jonathan B. Toledo, Juan C. Troncoso, Jean Paul Vonsattel, Charles L. White, Thomas Wisniewski, Randall L. Woltjer, Masahito Yamada, Peter T. Nelson |
| Abstract |
We recommend a new term, "primary age-related tauopathy" (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many autopsy studies have reported brains with neurofibrillary tangles (NFTs) that are indistinguishable from those of Alzheimer's disease (AD), in the absence of amyloid (Aβ) plaques. For these "NFT+/Aβ-" brains, for which formal criteria for AD neuropathologic changes are not met, the NFTs are mostly restricted to structures in the medial temporal lobe, basal forebrain, brainstem, and olfactory areas (bulb and cortex). Symptoms in persons with PART usually range from normal to amnestic cognitive changes, with only a minority exhibiting profound impairment. Because cognitive impairment is often mild, existing clinicopathologic designations, such as "tangle-only dementia" and "tangle-predominant senile dementia", are imprecise and not appropriate for most subjects. PART is almost universally detectable at autopsy among elderly individuals, yet this pathological process cannot be specifically identified pre-mortem at the present time. Improved biomarkers and tau imaging may enable diagnosis of PART in clinical settings in the future. Indeed, recent studies have identified a common biomarker profile consisting of temporal lobe atrophy and tauopathy without evidence of Aβ accumulation. For both researchers and clinicians, a revised nomenclature will raise awareness of this extremely common pathologic change while providing a conceptual foundation for future studies. Prior reports that have elucidated features of the pathologic entity we refer to as PART are discussed, and working neuropathological diagnostic criteria are proposed. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 10 | 40% |
| United States | 3 | 12% |
| Japan | 2 | 8% |
| Unknown | 10 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 60% |
| Scientists | 7 | 28% |
| Science communicators (journalists, bloggers, editors) | 3 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 730 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| United Kingdom | 3 | <1% |
| Japan | 3 | <1% |
| Spain | 3 | <1% |
| Netherlands | 1 | <1% |
| Portugal | 1 | <1% |
| Canada | 1 | <1% |
| Philippines | 1 | <1% |
| Unknown | 712 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 121 | 17% |
| Researcher | 106 | 15% |
| Student > Master | 78 | 11% |
| Student > Bachelor | 68 | 9% |
| Other | 47 | 6% |
| Other | 136 | 19% |
| Unknown | 174 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 168 | 23% |
| Medicine and Dentistry | 136 | 19% |
| Agricultural and Biological Sciences | 67 | 9% |
| Biochemistry, Genetics and Molecular Biology | 42 | 6% |
| Psychology | 36 | 5% |
| Other | 78 | 11% |
| Unknown | 203 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 83. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2023.
All research outputs
#524,438
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Outputs from Acta Neuropathologica
#66
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#5,453
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Outputs of similar age from Acta Neuropathologica
#2
of 26 outputs
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