Title |
A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
|
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Published in |
JACC: Basic to Translational Science, October 2017
|
DOI | 10.1016/j.jacbts.2017.06.003 |
Pubmed ID | |
Authors |
Jose R. Garcia, Peter F. Campbell, Gautam Kumar, Jonathan J. Langberg, Liliana Cesar, Lanfang Wang, Andrés J. García, Rebecca D. Levit |
Abstract |
Biomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydrogel delivery and gelation using anatomic structures. The method minimizes risk to patients from embolization, thrombotic occlusion, and arrhythmia. In pigs there were no clinically relevant acute or subacute adverse effects from pericardial hydrogel delivery, making this a translatable strategy to deliver biomaterials to the heart. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 40% |
Georgia | 1 | 7% |
Colombia | 1 | 7% |
Spain | 1 | 7% |
Mexico | 1 | 7% |
Netherlands | 1 | 7% |
Unknown | 4 | 27% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 80% |
Scientists | 1 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 7% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 18% |
Student > Master | 9 | 16% |
Researcher | 7 | 13% |
Student > Bachelor | 5 | 9% |
Professor > Associate Professor | 3 | 5% |
Other | 7 | 13% |
Unknown | 14 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 12 | 22% |
Medicine and Dentistry | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 7 | 13% |
Agricultural and Biological Sciences | 4 | 7% |
Chemical Engineering | 2 | 4% |
Other | 2 | 4% |
Unknown | 19 | 35% |