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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
|
|---|---|
| Published in |
Nature Medicine, October 2014
|
| DOI | 10.1038/nm.3708 |
| Pubmed ID | |
| Authors |
Antonella Sistigu, Takahiro Yamazaki, Erika Vacchelli, Kariman Chaba, David P Enot, Julien Adam, Ilio Vitale, Aicha Goubar, Elisa E Baracco, Catarina Remédios, Laetitia Fend, Dalil Hannani, Laetitia Aymeric, Yuting Ma, Mireia Niso-Santano, Oliver Kepp, Joachim L Schultze, Thomas Tüting, Filippo Belardelli, Laura Bracci, Valentina La Sorsa, Giovanna Ziccheddu, Paola Sestili, Francesca Urbani, Mauro Delorenzi, Magali Lacroix-Triki, Virginie Quidville, Rosa Conforti, Jean-Philippe Spano, Lajos Pusztai, Vichnou Poirier-Colame, Suzette Delaloge, Frederique Penault-Llorca, Sylvain Ladoire, Laurent Arnould, Joanna Cyrta, Marie-Charlotte Dessoliers, Alexander Eggermont, Marco E Bianchi, Mikael Pittet, Camilla Engblom, Christina Pfirschke, Xavier Préville, Gilles Uzè, Robert D Schreiber, Melvyn T Chow, Mark J Smyth, Enrico Proietti, Fabrice André, Guido Kroemer, Laurence Zitvogel |
| Abstract |
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3). By binding to IFN-α and IFN-β receptors (IFNARs) on neoplastic cells, type I IFNs trigger autocrine and paracrine circuitries that result in the release of chemokine (C-X-C motif) ligand 10 (CXCL10). Tumors lacking Tlr3 or Ifnar failed to respond to chemotherapy unless type I IFN or Cxcl10, respectively, was artificially supplied. Moreover, a type I IFN-related signature predicted clinical responses to anthracycline-based chemotherapy in several independent cohorts of patients with breast carcinoma characterized by poor prognosis. Our data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens. We surmise that such 'viral mimicry' constitutes a hallmark of successful chemotherapy. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 11% |
| United Kingdom | 2 | 11% |
| United States | 1 | 6% |
| Armenia | 1 | 6% |
| Belgium | 1 | 6% |
| New Zealand | 1 | 6% |
| Canada | 1 | 6% |
| Unknown | 9 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 78% |
| Science communicators (journalists, bloggers, editors) | 2 | 11% |
| Scientists | 2 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 675 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| Spain | 3 | <1% |
| France | 1 | <1% |
| Norway | 1 | <1% |
| Australia | 1 | <1% |
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| United Kingdom | 1 | <1% |
| Unknown | 661 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 140 | 21% |
| Researcher | 134 | 20% |
| Student > Master | 62 | 9% |
| Student > Doctoral Student | 42 | 6% |
| Student > Bachelor | 39 | 6% |
| Other | 122 | 18% |
| Unknown | 136 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 134 | 20% |
| Agricultural and Biological Sciences | 122 | 18% |
| Medicine and Dentistry | 104 | 15% |
| Immunology and Microbiology | 85 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 3% |
| Other | 47 | 7% |
| Unknown | 166 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2023.
All research outputs
#1,287,836
of 26,017,215 outputs
Outputs from Nature Medicine
#2,864
of 9,421 outputs
Outputs of similar age
#14,286
of 277,923 outputs
Outputs of similar age from Nature Medicine
#43
of 108 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 105.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,923 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 108 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.