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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response
|
|---|---|
| Published in |
Pharmacology & Therapeutics, November 2017
|
| DOI | 10.1016/j.pharmthera.2017.10.017 |
| Pubmed ID | |
| Authors |
Sabine Hombach-Klonisch, Maryam Mehrpour, Shahla Shojaei, Craig Harlos, Marshall Pitz, Ahmed Hamai, Krzysztof Siemianowicz, Wirginia Likus, Emilia Wiechec, Brian D. Toyota, Reyhane Hoshyar, Amir Seyfoori, Zahra Sepehri, Sudharsana R. Ande, Forough Khadem, Mohsen Akbari, Adrienne M. Gorman, Afshin Samali, Thomas Klonisch, Saeid Ghavami |
| Abstract |
Despite advances in neurosurgical techniques and radio-/ chemotherapy, the treatment of brain tumors remains a challenge. This is particularly true for the most frequent and fatal adult brain tumor, glioblastoma (GB). Upon diagnosis, the average survival time of GB patients remains only approximately 15 months. The alkylating drug temozolomide (TMZ) is routinely used in brain tumor patients and induces apoptosis, autophagy and unfolded protein response (UPR). Here, we review these cellular mechanisms and their contributions to TMZ chemoresistance in brain tumors, with a particular emphasis on TMZ chemoresistance in glioma stem cells and GB. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 4 | 50% |
| Chile | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 63% |
| Scientists | 2 | 25% |
| Unknown | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 201 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 33 | 16% |
| Student > Ph. D. Student | 25 | 12% |
| Student > Doctoral Student | 20 | 10% |
| Student > Bachelor | 16 | 8% |
| Researcher | 15 | 7% |
| Other | 31 | 15% |
| Unknown | 61 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 45 | 22% |
| Medicine and Dentistry | 23 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 6% |
| Agricultural and Biological Sciences | 11 | 5% |
| Neuroscience | 7 | 3% |
| Other | 29 | 14% |
| Unknown | 73 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2023.
All research outputs
#2,074,163
of 25,554,853 outputs
Outputs from Pharmacology & Therapeutics
#158
of 2,389 outputs
Outputs of similar age
#40,441
of 343,224 outputs
Outputs of similar age from Pharmacology & Therapeutics
#6
of 31 outputs
Altmetric has tracked 25,554,853 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,389 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,224 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.