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Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids

Overview of attention for article published in Nature Communications, October 2014
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Title
Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids
Published in
Nature Communications, October 2014
DOI 10.1038/ncomms6338
Pubmed ID
Authors

Natsuki Kondo, Yusuke Ohno, Maki Yamagata, Takashi Obara, Naoya Seki, Takuya Kitamura, Tatsuro Naganuma, Akio Kihara

Abstract

The long-chain base phytosphingosine is a component of sphingolipids and exists in yeast, plants and some mammalian tissues. Phytosphingosine is unique in that it possesses an additional hydroxyl group compared with other long-chain bases. However, its metabolism is unknown. Here we show that phytosphingosine is metabolized to odd-numbered fatty acids and is incorporated into glycerophospholipids both in yeast and mammalian cells. Disruption of the yeast gene encoding long-chain base 1-phosphate lyase, which catalyzes the committed step in the metabolism of phytosphingosine to glycerophospholipids, causes an ~40% reduction in the level of phosphatidylcholines that contain a C15 fatty acid. We also find that 2-hydroxypalmitic acid is an intermediate of the phytosphingosine metabolic pathway. Furthermore, we show that the yeast MPO1 gene, whose product belongs to a large, conserved protein family of unknown function, is involved in phytosphingosine metabolism. Our findings provide insights into fatty acid diversity and identify a pathway by which hydroxyl group-containing lipids are metabolized.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 <1%
Germany 1 <1%
Canada 1 <1%
Unknown 98 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 24 24%
Student > Ph. D. Student 22 22%
Other 9 9%
Student > Master 9 9%
Professor 5 5%
Other 14 14%
Unknown 18 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 27%
Biochemistry, Genetics and Molecular Biology 23 23%
Chemistry 9 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Engineering 3 3%
Other 10 10%
Unknown 26 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2014.
All research outputs
#17,730,142
of 22,768,097 outputs
Outputs from Nature Communications
#43,131
of 46,898 outputs
Outputs of similar age
#175,393
of 260,282 outputs
Outputs of similar age from Nature Communications
#643
of 748 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 46,898 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,282 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 748 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.