Title |
Verbal working memory and functional large-scale networks in schizophrenia
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Published in |
Psychiatry Research: Neuroimaging Section, October 2017
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DOI | 10.1016/j.pscychresns.2017.10.004 |
Pubmed ID | |
Authors |
Maria R. Dauvermann, Thomas WJ Moorhead, Andrew R. Watson, Barbara Duff, Liana Romaniuk, Jeremy Hall, Neil Roberts, Graham L. Lee, Zoë A. Hughes, Nicholas J. Brandon, Brandon Whitcher, Douglas HR Blackwood, Andrew M. McIntosh, Stephen M. Lawrie |
Abstract |
The aim of this study was to test whether bilinear and nonlinear effective connectivity (EC) measures of working memory fMRI data can differentiate between patients with schizophrenia (SZ) and healthy controls (HC). We applied bilinear and nonlinear Dynamic Causal Modeling (DCM) for the analysis of verbal working memory in 16 SZ and 21 HC. The connection strengths with nonlinear modulation between the dorsolateral prefrontal cortex (DLPFC) and the ventral tegmental area/substantia nigra (VTA/SN) were evaluated. We used Bayesian Model Selection at the group and family levels to compare the optimal bilinear and nonlinear models. Bayesian Model Averaging was used to assess the connection strengths with nonlinear modulation. The DCM analyses revealed that SZ and HC used different bilinear networks despite comparable behavioral performance. In addition, the connection strengths with nonlinear modulation between the DLPFC and the VTA/SN area showed differences between SZ and HC. The adoption of different functional networks in SZ and HC indicated neurobiological alterations underlying working memory performance, including different connection strengths with nonlinear modulation between the DLPFC and the VTA/SN area. These novel findings may increase our understanding of connectivity in working memory in schizophrenia. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 14 | 23% |
Student > Bachelor | 9 | 15% |
Researcher | 9 | 15% |
Student > Ph. D. Student | 8 | 13% |
Professor | 3 | 5% |
Other | 6 | 10% |
Unknown | 13 | 21% |
Readers by discipline | Count | As % |
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Psychology | 16 | 26% |
Neuroscience | 12 | 19% |
Medicine and Dentistry | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 2 | 3% |
Computer Science | 2 | 3% |
Other | 7 | 11% |
Unknown | 19 | 31% |