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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study
|
|---|---|
| Published in |
Molecular Psychiatry, December 2014
|
| DOI | 10.1038/mp.2014.133 |
| Pubmed ID | |
| Authors |
D J Gottlieb, K Hek, T-h Chen, N F Watson, G Eiriksdottir, E M Byrne, M Cornelis, S C Warby, S Bandinelli, L Cherkas, D S Evans, H J Grabe, J Lahti, M Li, T Lehtimäki, T Lumley, K D Marciante, L Pérusse, B M Psaty, J Robbins, G J Tranah, J M Vink, J B Wilk, J M Stafford, C Bellis, R Biffar, C Bouchard, B Cade, G C Curhan, J G Eriksson, R Ewert, L Ferrucci, T Fülöp, P R Gehrman, R Goodloe, T B Harris, A C Heath, D Hernandez, A Hofman, J-J Hottenga, D J Hunter, M K Jensen, A D Johnson, M Kähönen, L Kao, P Kraft, E K Larkin, D S Lauderdale, A I Luik, M Medici, G W Montgomery, A Palotie, S R Patel, G Pistis, E Porcu, L Quaye, O Raitakari, S Redline, E B Rimm, J I Rotter, A V Smith, T D Spector, A Teumer, A G Uitterlinden, M-C Vohl, E Widen, G Willemsen, T Young, X Zhang, Y Liu, J Blangero, D I Boomsma, V Gudnason, F Hu, M Mangino, N G Martin, G T O'Connor, K L Stone, T Tanaka, J Viikari, S A Gharib, N M Punjabi, K Räikkönen, H Völzke, E Mignot, H Tiemeier |
| Abstract |
Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.Molecular Psychiatry advance online publication, 18 November 2014; doi:10.1038/mp.2014.133. |
X Demographics
The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 20% |
| Australia | 5 | 17% |
| Netherlands | 3 | 10% |
| United States | 2 | 7% |
| Spain | 2 | 7% |
| Japan | 1 | 3% |
| Russia | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 9 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 73% |
| Scientists | 7 | 23% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Finland | 1 | <1% |
| United Kingdom | 1 | <1% |
| Singapore | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 224 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 46 | 20% |
| Student > Ph. D. Student | 36 | 16% |
| Student > Master | 22 | 10% |
| Student > Bachelor | 22 | 10% |
| Student > Doctoral Student | 20 | 9% |
| Other | 42 | 18% |
| Unknown | 41 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 42 | 18% |
| Psychology | 28 | 12% |
| Biochemistry, Genetics and Molecular Biology | 26 | 11% |
| Agricultural and Biological Sciences | 23 | 10% |
| Nursing and Health Professions | 15 | 7% |
| Other | 45 | 20% |
| Unknown | 50 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 84. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2021.
All research outputs
#514,127
of 26,017,215 outputs
Outputs from Molecular Psychiatry
#475
of 4,689 outputs
Outputs of similar age
#5,982
of 375,262 outputs
Outputs of similar age from Molecular Psychiatry
#6
of 50 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,689 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 39.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 375,262 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.