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Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis

Overview of attention for article published in Frontiers in Microbiology, October 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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5 X users
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2 patents
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1 YouTube creator

Citations

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90 Dimensions

Readers on

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159 Mendeley
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Title
Nitric Oxide in the Pathogenesis and Treatment of Tuberculosis
Published in
Frontiers in Microbiology, October 2017
DOI 10.3389/fmicb.2017.02008
Pubmed ID
Authors

Hamidreza Jamaati, Esmaeil Mortaz, Zeinab Pajouhi, Gert Folkerts, Mehrnaz Movassaghi, Milad Moloudizargari, Ian M. Adcock, Johan Garssen

Abstract

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is globally known as one of the most important human pathogens. Mtb is estimated to infect nearly one third of the world's population with many subjects having a latent infection. Thus, from an estimated 2 billion people infected with Mtb, less than 10% may develop symptomatic TB. This indicates that the host immune system may constrain pathogen replication in most infected individuals. On entering the lungs of the host, Mtb initially encounters resident alveolar macrophages which can engulf and subsequently eliminate intracellular microbes via a plethora of bactericidal mechanisms including the generation of free radicals such as reactive oxygen and nitrogen species. Nitric oxide (NO), a key anti-mycobacterial molecule, is detected in the exhaled breath of patients infected with Mtb. Recent knowledge regarding the regulatory role of NO in airway function and Mtb proliferation paves the way of exploiting the beneficial effects of this molecule for the treatment of airway diseases. Here, we discuss the importance of NO in the pathogenesis of TB, the diagnostic use of exhaled and urinary NO in Mtb infection and the potential of NO-based treatments.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 159 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 16%
Researcher 21 13%
Student > Master 21 13%
Student > Doctoral Student 14 9%
Student > Bachelor 13 8%
Other 18 11%
Unknown 47 30%
Readers by discipline Count As %
Immunology and Microbiology 30 19%
Medicine and Dentistry 18 11%
Biochemistry, Genetics and Molecular Biology 18 11%
Agricultural and Biological Sciences 11 7%
Pharmacology, Toxicology and Pharmaceutical Science 8 5%
Other 19 12%
Unknown 55 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#3,599,097
of 25,576,801 outputs
Outputs from Frontiers in Microbiology
#3,200
of 29,566 outputs
Outputs of similar age
#63,467
of 334,669 outputs
Outputs of similar age from Frontiers in Microbiology
#95
of 518 outputs
Altmetric has tracked 25,576,801 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 29,566 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,669 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 518 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.