| Title |
Psilocybin with psychological support improves emotional face recognition in treatment-resistant depression
|
|---|---|
| Published in |
Psychopharmacology, October 2017
|
| DOI | 10.1007/s00213-017-4754-y |
| Pubmed ID | |
| Authors |
J. B. Stroud, T. P. Freeman, R. Leech, C. Hindocha, W. Lawn, D.J. Nutt, H.V Curran, R. L. Carhart-Harris |
| Abstract |
Depressed patients robustly exhibit affective biases in emotional processing which are altered by SSRIs and predict clinical outcome. The objective of this study is to investigate whether psilocybin, recently shown to rapidly improve mood in treatment-resistant depression (TRD), alters patients' emotional processing biases. Seventeen patients with treatment-resistant depression completed a dynamic emotional face recognition task at baseline and 1 month later after two doses of psilocybin with psychological support. Sixteen controls completed the emotional recognition task over the same time frame but did not receive psilocybin. We found evidence for a group × time interaction on speed of emotion recognition (p = .035). At baseline, patients were slower at recognising facial emotions compared with controls (p < .001). After psilocybin, this difference was remediated (p = .208). Emotion recognition was faster at follow-up compared with baseline in patients (p = .004, d = .876) but not controls (p = .263, d = .302). In patients, this change was significantly correlated with a reduction in anhedonia over the same time period (r = .640, p = .010). Psilocybin with psychological support appears to improve processing of emotional faces in treatment-resistant depression, and this correlates with reduced anhedonia. Placebo-controlled studies are warranted to follow up these preliminary findings. |
X Demographics
The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 12 | 30% |
| United Kingdom | 5 | 13% |
| Canada | 2 | 5% |
| Australia | 1 | 3% |
| France | 1 | 3% |
| Iceland | 1 | 3% |
| Chile | 1 | 3% |
| Unknown | 17 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 33 | 83% |
| Scientists | 6 | 15% |
| Practitioners (doctors, other healthcare professionals) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 312 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 312 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 68 | 22% |
| Student > Master | 39 | 13% |
| Researcher | 25 | 8% |
| Student > Ph. D. Student | 21 | 7% |
| Other | 15 | 5% |
| Other | 36 | 12% |
| Unknown | 108 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 64 | 21% |
| Medicine and Dentistry | 44 | 14% |
| Neuroscience | 34 | 11% |
| Agricultural and Biological Sciences | 11 | 4% |
| Biochemistry, Genetics and Molecular Biology | 7 | 2% |
| Other | 32 | 10% |
| Unknown | 120 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2024.
All research outputs
#896,058
of 25,750,437 outputs
Outputs from Psychopharmacology
#230
of 5,356 outputs
Outputs of similar age
#18,626
of 340,806 outputs
Outputs of similar age from Psychopharmacology
#6
of 45 outputs
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So far Altmetric has tracked 5,356 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.1. This one has done particularly well, scoring higher than 95% of its peers.
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