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Mendeley readers
Attention Score in Context
| Title |
Genetic comorbidities in Parkinson's disease
|
|---|---|
| Published in |
Human Molecular Genetics, September 2013
|
| DOI | 10.1093/hmg/ddt465 |
| Pubmed ID | |
| Authors |
Mike A. Nalls, Mohamad Saad, Alastair J. Noyce, Margaux F. Keller, Anette Schrag, Jonathan P. Bestwick, Bryan J. Traynor, J. Raphael Gibbs, Dena G. Hernandez, Mark R. Cookson, Huw R. Morris, Nigel Williams, Thomas Gasser, Peter Heutink, Nick Wood, John Hardy, Maria Martinez, Andrew B. Singleton |
| Abstract |
Parkinson's disease (PD) has a number of known genetic risk factors. Clinical and epidemiological studies have suggested the existence of intermediate factors that may be associated with additional risk of PD. We construct genetic risk profiles for additional epidemiological and clinical factors using known genome-wide association studies (GWAS) loci related to these specific phenotypes to estimate genetic comorbidity in a systematic review. We identify genetic risk profiles based on GWAS variants associated with schizophrenia and Crohn's disease as significantly associated with risk of PD. Conditional analyses adjusting for SNPs near loci associated with PD and schizophrenia or PD and Crohn's disease suggest that spatially overlapping loci associated with schizophrenia and PD account for most of the shared comorbidity, while variation outside of known proximal loci shared by PD and Crohn's disease accounts for their shared genetic comorbidity. We examine brain methylation and expression signatures proximal to schizophrenia and Crohn's disease loci to infer functional changes in the brain associated with the variants contributing to genetic comorbidity. We compare our results with a systematic review of epidemiological literature, while the findings are dissimilar to a degree; marginal genetic associations corroborate the directionality of associations across genetic and epidemiological data. We show a strong genetically defined level of comorbidity between PD and Crohn's disease as well as between PD and schizophrenia, with likely functional consequences of associated variants occurring in brain. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 2 | 2% |
| Unknown | 120 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 21% |
| Student > Ph. D. Student | 20 | 16% |
| Student > Master | 20 | 16% |
| Student > Bachelor | 12 | 10% |
| Professor | 9 | 7% |
| Other | 25 | 20% |
| Unknown | 13 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 27% |
| Agricultural and Biological Sciences | 23 | 18% |
| Neuroscience | 19 | 15% |
| Biochemistry, Genetics and Molecular Biology | 8 | 6% |
| Psychology | 4 | 3% |
| Other | 14 | 11% |
| Unknown | 23 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2014.
All research outputs
#15,703,951
of 23,337,345 outputs
Outputs from Human Molecular Genetics
#6,745
of 8,069 outputs
Outputs of similar age
#125,293
of 203,214 outputs
Outputs of similar age from Human Molecular Genetics
#76
of 117 outputs
Altmetric has tracked 23,337,345 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,069 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.