Title |
Interaction of quantitative 18F‐FDG‐PET‐CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma
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Published in |
Head & Neck, May 2015
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DOI | 10.1002/hed.23920 |
Pubmed ID | |
Authors |
Charlotte S Schouten, Sara Hakim, R Boellaard, Elisabeth Bloemena, Patricia A Doornaert, Birgit I Witte, Boudewijn J M Braakhuis, Ruud H Brakenhoff, C René Leemans, Otto S Hoekstra, Remco de Bree |
Abstract |
Background. Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) have a better survival than HPV-negative OPSCC. 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG-PET-CT) may also provide prognostic information. We evaluated glycolytic characteristics in HPV-negative and HPV-positive OPSCC. Methods. Forty-four patients underwent pretreatment 18F-FDG-PET-CT. Standardized Uptake Values (SUV) and metabolic active tumor volume (MATV) were determined for primary tumors. HPV-status was determined with p16 immunostaining, followed by high-risk HPV DNA detection on the positive cases. Results. Twenty-seven patients were HPV-positive (61.4%). Median MATV was 2.8 millilitres (ml) [1.6-5.1] for HPV-positive and 6.0 ml [4.4-18.7] for HPV-negative tumors (p<0.001). SUV-values are volume dependent (partial volume effect), therefore, MATV was included as covariate in multivariate analysis. The maximum SUV in HPV-positive was 3.9 units lower than in HPV-negative tumors (p=0.01). Conclusions. 18F-FDG-PET-CT parameters are lower in HPV-positive than in HPV-negative patients. Low pretreatment SUV-values in HPV-positive OPSCC may be at least partly explained by HPV-induced tumor changes. Head Neck, 2014. |
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