Title |
Diagnostic strategies for subclinical hypothyroidism
|
---|---|
Published in |
Indian Journal of Clinical Biochemistry, October 2008
|
DOI | 10.1007/s12291-008-0062-y |
Pubmed ID | |
Authors |
Shruti Mohanty, W. Amruthlal, G. C. Reddy, G. Kusumanjali, A. S. Kanagasabapathy, Pragna Rao |
Abstract |
The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri - iodothyronine (T(3)), thyroxine (T(4)), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Postgraduate | 6 | 23% |
Student > Bachelor | 3 | 12% |
Other | 3 | 12% |
Professor | 2 | 8% |
Researcher | 2 | 8% |
Other | 3 | 12% |
Unknown | 7 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 46% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Social Sciences | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Unknown | 8 | 31% |