| Title |
Formation and role of exosomes in cancer
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2014
|
| DOI | 10.1007/s00018-014-1764-3 |
| Pubmed ID | |
| Authors |
Lindsey T. Brinton, Hillary S. Sloane, Mark Kester, Kimberly A. Kelly |
| Abstract |
Exosomes offer new insight into cancer biology with both diagnostic and therapeutic implications. Because of their cell-to-cell communication, exosomes influence tumor progression, metastasis, and therapeutic efficacy. They can be isolated from blood and other bodily fluids to reveal disease processes occurring within the body, including cancerous growth. In addition to being a reservoir of cancer biomarkers, they can be re-engineered to reinstate tumor immunity. Tumor exosomes interact with various cells of the microenvironment to confer tumor-advantageous changes that are responsible for stromal activation, induction of the angiogenic switch, increased vascular permeability, and immune escape. Exosomes also contribute to metastasis by aiding in the epithelial-to-mesenchymal transition and formation of the pre-metastatic niche. Furthermore, exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells. Thus, exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 316 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Netherlands | 1 | <1% |
| Denmark | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 309 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 63 | 20% |
| Researcher | 42 | 13% |
| Student > Master | 40 | 13% |
| Student > Bachelor | 40 | 13% |
| Student > Doctoral Student | 23 | 7% |
| Other | 55 | 17% |
| Unknown | 53 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 77 | 24% |
| Agricultural and Biological Sciences | 59 | 19% |
| Medicine and Dentistry | 54 | 17% |
| Engineering | 15 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 36 | 11% |
| Unknown | 65 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2017.
All research outputs
#7,315,081
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#1,552
of 4,151 outputs
Outputs of similar age
#78,407
of 262,040 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#15
of 57 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,040 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 57 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.