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Mendeley readers
| Title |
KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL
|
|---|---|
| Published in |
Blood, August 2014
|
| DOI | 10.1182/blood-2014-03-565069 |
| Pubmed ID | |
| Authors |
Lena Oevermann, Sebastian U Michaelis, Markus Mezger, Peter Lang, Jacek Toporski, Alice Bertaina, Marco Zecca, Lorenzo Moretta, Franco Locatelli, Rupert Handgretinger |
| Abstract |
We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score. |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| France | 1 | 1% |
| Italy | 1 | 1% |
| Brazil | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 77 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 28% |
| Student > Ph. D. Student | 11 | 13% |
| Student > Bachelor | 8 | 10% |
| Student > Doctoral Student | 7 | 9% |
| Other | 7 | 9% |
| Other | 11 | 13% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 43% |
| Agricultural and Biological Sciences | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Immunology and Microbiology | 8 | 10% |
| Nursing and Health Professions | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 16 | 20% |