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Ghrelin’s Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders

Overview of attention for article published in Biological Psychiatry, October 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

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5 X users
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3 patents
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3 Facebook pages
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1 Wikipedia page
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1 Google+ user

Citations

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101 Dimensions

Readers on

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159 Mendeley
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Title
Ghrelin’s Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders
Published in
Biological Psychiatry, October 2014
DOI 10.1016/j.biopsych.2014.10.021
Pubmed ID
Authors

Sarah J. Spencer, Tim L. Emmerzaal, Tamas Kozicz, Zane B. Andrews

Abstract

Ghrelin is a stomach hormone normally associated with feeding behavior and energy homeostasis. Recent studies highlight that ghrelin targets the brain to regulate a diverse number of functions, including learning, memory, motivation, stress responses, anxiety, and mood. In this review, we discuss recent animal and human studies showing that ghrelin regulates the hypothalamic-pituitary-adrenal axis and affects anxiety and mood disorders, such as depression and fear. We address the neural sites of action through which ghrelin regulates the hypothalamic-pituitary-adrenal axis and associated stress-induced behaviors, including the centrally projecting Edinger-Westphal nucleus, the hippocampus, amygdala, locus coeruleus, and the ventral tegmental area. Stressors modulate many behaviors associated with motivation, fear, anxiety, depression, and appetite; therefore, we assess the potential role for ghrelin as a stress feedback signal that regulates these associated behaviors. Finally, we briefly discuss important areas for future research that will help us move closer to potential ghrelin-based therapies to treat stress responses and related disorders.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 159 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Canada 1 <1%
Brazil 1 <1%
Unknown 156 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 27 17%
Student > Bachelor 22 14%
Student > Ph. D. Student 21 13%
Researcher 19 12%
Other 10 6%
Other 28 18%
Unknown 32 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 17%
Neuroscience 26 16%
Psychology 22 14%
Medicine and Dentistry 21 13%
Biochemistry, Genetics and Molecular Biology 7 4%
Other 20 13%
Unknown 36 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2023.
All research outputs
#3,322,273
of 25,654,806 outputs
Outputs from Biological Psychiatry
#1,880
of 6,624 outputs
Outputs of similar age
#37,113
of 275,175 outputs
Outputs of similar age from Biological Psychiatry
#30
of 83 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,624 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,175 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.