| Title |
Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus
|
|---|---|
| Published in |
Osteoporosis International, September 2009
|
| DOI | 10.1007/s00198-009-1066-z |
| Pubmed ID | |
| Authors |
M. Saito, K. Marumo |
| Abstract |
Collagen cross-linking, a major post-translational modification of collagen, plays important roles in the biological and biomechanical features of bone. Collagen cross-links can be divided into lysyl hydroxylase and lysyloxidase-mediated enzymatic immature divalent cross-links,mature trivalent pyridinoline and pyrrole cross-links, and glycation- or oxidation-induced non-enzymatic cross-links(advanced glycation end products) such as glucosepane and pentosidine. These types of cross-links differ in the mechanism of formation and in function. Material properties of newly synthesized collagen matrix may differ in tissue maturity and senescence from older matrix in terms of crosslink formation. Additionally, newly synthesized matrix in osteoporotic patients or diabetic patients may not necessarily be as well-made as age-matched healthy subjects. Data have accumulated that collagen cross-link formation affects not only the mineralization process but also microdamage formation. Consequently, collagen cross-linking is thought to affect the mechanical properties of bone. Furthermore,recent basic and clinical investigations of collagen cross-links seem to face a new era. For instance, serum or urine pentosidine levels are now being used to estimate future fracture risk in osteoporosis and diabetes. In this review, we describe age-related changes in collagen cross-links in bone and abnormalities of cross-links in osteoporosis and diabetes that have been reported in the literature. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 1 | 25% |
| Chile | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 515 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 3 | <1% |
| Brazil | 2 | <1% |
| Japan | 2 | <1% |
| Netherlands | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| Denmark | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 499 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 131 | 25% |
| Student > Master | 75 | 15% |
| Researcher | 68 | 13% |
| Student > Bachelor | 36 | 7% |
| Professor > Associate Professor | 32 | 6% |
| Other | 82 | 16% |
| Unknown | 91 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 114 | 22% |
| Engineering | 79 | 15% |
| Agricultural and Biological Sciences | 66 | 13% |
| Biochemistry, Genetics and Molecular Biology | 43 | 8% |
| Materials Science | 20 | 4% |
| Other | 76 | 15% |
| Unknown | 117 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2024.
All research outputs
#2,277,587
of 22,769,322 outputs
Outputs from Osteoporosis International
#369
of 3,604 outputs
Outputs of similar age
#7,542
of 93,592 outputs
Outputs of similar age from Osteoporosis International
#2
of 13 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,604 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,592 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.