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The Effect of Compliant Inflow Cannulae on the Hemocompatibility of Rotary Blood Pump Circuits in an In Vitro Model

Overview of attention for article published in Artificial Organs, June 2017
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Title
The Effect of Compliant Inflow Cannulae on the Hemocompatibility of Rotary Blood Pump Circuits in an In Vitro Model
Published in
Artificial Organs, June 2017
DOI 10.1111/aor.12919
Pubmed ID
Authors

Jo P. Pauls, Deepika Nandakumar, Jarod Horobin, Justin D. Prendeville, Michael J. Simmonds, John F. Fraser, Geoff Tansley, Shaun D. Gregory

Abstract

Rotary blood pumps (RBPs) are used for mechanical circulatory support in heart failure patients but exhibit a reduced response to preload changes, which can lead to ventricular suction events. A passive control system, in the form of a compliant inflow cannula (IC), has been developed to mitigate suction, although this device may cause significant hemolysis. This study compared the incidence of mechanically induced hemolysis of two compliant IC designs (strutted and nonstrutted) with a rigid IC (control) in a blood circulation loop over 90 min. The nonstrutted compliant IC introduced high frequency and high amplitude oscillations in RBP inlet pressure and RBP IC resistance. These oscillations were correlated with a significant increase in plasma-free hemoglobin (pfHb) and hemolysis: pfHb increased to 2.005 ± 0.665 g/L, while normalized index of hemolysis (NIH) and modified index of hemolysis (MIH) increased to 0.04945 ± 0.01276 g/100 L and 4.0505 ± 0.6589 after 90 min (P < 0.05). In contrast, the strutted compliant IC performed similar to the clinically utilized rigid IC and did not increase pfHb (0.300 ± 0.090 and 0.320 ± 0.171 g/L, respectively) and rate of hemolysis (NIH 0.00435 ± 0.00155 and 0.00543 ± 0.00371 g/100 L; MIH 0.3896 ± 0.1749 and 0.4261 ± 0.2792, respectively) within the RBP circuit. These data indicated that strutted, compliant ICs meet the hemocompatibility of clinically used rigid ICs while also offering a potential solution to prevent ventricular suction events.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 21%
Student > Ph. D. Student 3 21%
Student > Postgraduate 2 14%
Professor 1 7%
Student > Doctoral Student 1 7%
Other 2 14%
Unknown 2 14%
Readers by discipline Count As %
Engineering 6 43%
Nursing and Health Professions 3 21%
Biochemistry, Genetics and Molecular Biology 2 14%
Medicine and Dentistry 1 7%
Unknown 2 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2017.
All research outputs
#19,294,717
of 24,565,648 outputs
Outputs from Artificial Organs
#1,558
of 1,916 outputs
Outputs of similar age
#215,171
of 295,931 outputs
Outputs of similar age from Artificial Organs
#13
of 25 outputs
Altmetric has tracked 24,565,648 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,916 research outputs from this source. They receive a mean Attention Score of 4.5. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.