Title |
Master regulatory role of p63 in epidermal development and disease
|
---|---|
Published in |
Cellular and Molecular Life Sciences, November 2017
|
DOI | 10.1007/s00018-017-2701-z |
Pubmed ID | |
Authors |
Eduardo Soares, Huiqing Zhou |
Abstract |
The transcription factor p63 is a master regulator of epidermal development. Mutations in p63 give rise to human developmental diseases that often manifest epidermal defects. In this review, we summarize major p63 isoforms identified so far and p63 mutation-associated human diseases that show epidermal defects. We discuss key roles of p63 in epidermal keratinocyte proliferation and differentiation, emphasizing its master regulatory control of the gene expression pattern and epigenetic landscape that define epidermal fate. We subsequently review the essential function of p63 during epidermal commitment and transdifferentiation towards epithelial lineages, highlighting the notion that p63 is the guardian of the epithelial lineage. Finally, we discuss current therapeutic development strategies for p63 mutation-associated diseases. Our review proposes future directions for dissecting p63-controlled mechanisms in normal and diseased epidermal development and for developing therapeutic options. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 169 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 20% |
Student > Bachelor | 22 | 13% |
Student > Master | 21 | 12% |
Researcher | 16 | 9% |
Student > Doctoral Student | 7 | 4% |
Other | 14 | 8% |
Unknown | 55 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 59 | 35% |
Agricultural and Biological Sciences | 27 | 16% |
Medicine and Dentistry | 9 | 5% |
Immunology and Microbiology | 4 | 2% |
Neuroscience | 4 | 2% |
Other | 7 | 4% |
Unknown | 59 | 35% |