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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tissue-specific regulation and function of Grb10 during growth and neuronal commitment
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, November 2014
|
| DOI | 10.1073/pnas.1411254111 |
| Pubmed ID | |
| Authors |
Robert N. Plasschaert, Marisa S. Bartolomei |
| Abstract |
Growth-factor receptor bound protein 10 (Grb10) is a signal adapter protein encoded by an imprinted gene that has roles in growth control, cellular proliferation, and insulin signaling. Additionally, Grb10 is critical for the normal behavior of the adult mouse. These functions are paralleled by Grb10's unique tissue-specific imprinted expression; the paternal copy of Grb10 is expressed in a subset of neurons whereas the maternal copy is expressed in most other adult tissues in the mouse. The mechanism that underlies this switch between maternal and paternal expression is still unclear, as is the role for paternally expressed Grb10 in neurons. Here, we review recent work and present complementary data that contribute to the understanding of Grb10 gene regulation and function, with specific emphasis on growth and neuronal development. Additionally, we show that in vitro differentiation of mouse embryonic stem cells into alpha motor neurons recapitulates the switch from maternal to paternal expression observed during neuronal development in vivo. We postulate that this switch in allele-specific expression is related to the functional role of Grb10 in motor neurons and other neuronal tissues. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 100 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 33% |
| Student > Bachelor | 12 | 12% |
| Researcher | 11 | 11% |
| Student > Master | 10 | 10% |
| Lecturer | 5 | 5% |
| Other | 15 | 14% |
| Unknown | 17 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 43 | 41% |
| Agricultural and Biological Sciences | 18 | 17% |
| Medicine and Dentistry | 9 | 9% |
| Neuroscience | 5 | 5% |
| Environmental Science | 2 | 2% |
| Other | 5 | 5% |
| Unknown | 22 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2015.
All research outputs
#19,337,766
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#95,933
of 101,438 outputs
Outputs of similar age
#182,594
of 267,701 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#839
of 960 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,701 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 960 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.