Title |
Neural Lineage Progression Controlled by a Temporal Proliferation Program
|
---|---|
Published in |
Developmental Cell, November 2017
|
DOI | 10.1016/j.devcel.2017.10.004 |
Pubmed ID | |
Authors |
Shahrzad Bahrampour, Erika Gunnar, Carolin Jonsson, Helen Ekman, Stefan Thor |
Abstract |
Great progress has been made in identifying transcriptional programs that establish stem cell identity. In contrast, we have limited insight into how these programs are down-graded in a timely manner to halt proliferation and allow for cellular differentiation. Drosophila embryonic neuroblasts undergo such a temporal progression, initially dividing to bud off daughters that divide once (type I), then switching to generating non-dividing daughters (type 0), and finally exiting the cell cycle. We identify six early transcription factors that drive neuroblast and type I daughter proliferation. Early factors are gradually replaced by three late factors, acting to trigger the type I→0 daughter proliferation switch and eventually to stop neuroblasts. Early and late factors regulate each other and four key cell-cycle genes, providing a logical genetic pathway for these transitions. The identification of this extensive driver-stopper temporal program controlling neuroblast lineage progression may have implications for studies in many other systems. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 20% |
Singapore | 1 | 10% |
United Kingdom | 1 | 10% |
France | 1 | 10% |
Sweden | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 50% |
Scientists | 5 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 21% |
Researcher | 11 | 20% |
Student > Bachelor | 8 | 14% |
Student > Master | 6 | 11% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 14% |
Unknown | 8 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 32% |
Biochemistry, Genetics and Molecular Biology | 17 | 30% |
Neuroscience | 7 | 13% |
Business, Management and Accounting | 2 | 4% |
Unspecified | 1 | 2% |
Other | 2 | 4% |
Unknown | 9 | 16% |