Title |
QChIPat: a quantitative method to identify distinct binding patterns for two biological ChIP-seq samples in different experimental conditions
|
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Published in |
BMC Genomics, December 2013
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DOI | 10.1186/1471-2164-14-s8-s3 |
Pubmed ID | |
Authors |
Bin Liu, Jimmy Yi, Aishwarya SV, Xun Lan, Yilin Ma, Tim HM Huang, Gustavo Leone, Victor X Jin |
Abstract |
Many computational programs have been developed to identify enriched regions for a single biological ChIP-seq sample. Given that many biological questions are often asked to compare the difference between two different conditions, it is important to develop new programs that address the comparison of two biological ChIP-seq samples. Despite several programs designed to address this question, these programs suffer from some drawbacks, such as inability to distinguish whether the identified differential enriched regions are indeed significantly enriched, lack of distinguishing binding patterns, and neglect of the normalization between samples. |
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