Title |
K13-Propeller Polymorphisms in Plasmodium falciparum Parasites From Sub-Saharan Africa
|
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Published in |
Journal of Infectious Diseases, November 2014
|
DOI | 10.1093/infdis/jiu608 |
Pubmed ID | |
Authors |
Edwin Kamau, Susana Campino, Lucas Amenga-Etego, Eleanor Drury, Deus Ishengoma, Kimberly Johnson, Dieudonne Mumba, Mihir Kekre, William Yavo, Daniel Mead, Marielle Bouyou-Akotet, Tobias Apinjoh, Lemu Golassa, Milijaona Randrianarivelojosia, Ben Andagalu, Oumou Maiga-Ascofare, Alfred Amambua-Ngwa, Paulina Tindana, Anita Ghansah, Bronwyn MacInnis, Dominic Kwiatkowski, Abdoulaye A. Djimde |
Abstract |
Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in South-East Asia (SEA). This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. 1212 P. falciparum samples collected from twelve countries were sequenced. None of the K13-propeller mutations previously reported in SEA were found, but 22 unique mutations were detected, of which seven were non-synonymous. Allele frequencies ranged between 1-3%. Three mutations were observed in more than one country, and the A578S was present in parasites from five countries. This study provides baseline prevalence of K13-propeller mutations in sub-Saharan Africa. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Ethiopia | 1 | 17% |
Madagascar | 1 | 17% |
Comoros | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | 1% |
Burkina Faso | 1 | <1% |
Ethiopia | 1 | <1% |
Tanzania, United Republic of | 1 | <1% |
Vietnam | 1 | <1% |
United States | 1 | <1% |
Unknown | 278 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 57 | 20% |
Student > Ph. D. Student | 54 | 19% |
Researcher | 52 | 18% |
Student > Bachelor | 22 | 8% |
Student > Doctoral Student | 12 | 4% |
Other | 44 | 15% |
Unknown | 46 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 78 | 27% |
Agricultural and Biological Sciences | 77 | 27% |
Medicine and Dentistry | 38 | 13% |
Immunology and Microbiology | 15 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
Other | 21 | 7% |
Unknown | 52 | 18% |