| Title |
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing
|
|---|---|
| Published in |
Brain Structure and Function, November 2017
|
| DOI | 10.1007/s00429-017-1547-3 |
| Pubmed ID | |
| Authors |
Aliza T. Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil M. Arefin, Christine Colley, Christian Le Gouill, Florence Gross, Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Laura-Adela Harsan, Michel Bouvier, Brigitte L. Kieffer |
| Abstract |
GPR88 is an orphan G-protein coupled receptor originally characterized as a striatal-enriched transcript and is a potential target for neuropsychiatric disorders. At present, gene knockout studies in the mouse have essentially focused on striatal-related functions and a comprehensive knowledge of GPR88 protein distribution and function in the brain is still lacking. Here, we first created Gpr88-Venus knock-in mice expressing a functional fluorescent receptor to fine-map GPR88 localization in the brain. The receptor protein was detected in neuronal soma, fibers and primary cilia depending on the brain region, and remarkably, whole-brain mapping revealed a yet unreported layer-4 cortical lamination pattern specifically in sensory processing areas. The unique GPR88 barrel pattern in L4 of the somatosensory cortex appeared 3 days after birth and persisted into adulthood, suggesting a potential function for GPR88 in sensory integration. We next examined Gpr88 knockout mice for cortical structure and behavioral responses in sensory tasks. Magnetic resonance imaging of live mice revealed abnormally high fractional anisotropy, predominant in somatosensory cortex and caudate putamen, indicating significant microstructural alterations in these GPR88-enriched areas. Further, behavioral analysis showed delayed responses in somatosensory-, visual- and olfactory-dependent tasks, demonstrating a role for GPR88 in the integration rather than perception of sensory stimuli. In conclusion, our data show for the first time a prominent role for GPR88 in multisensory processing. Because sensory integration is disrupted in many psychiatric diseases, our study definitely positions GPR88 as a target to treat mental disorders perhaps via activity on cortical sensory networks. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 25% |
| United States | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 50% |
| Members of the public | 4 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 24% |
| Student > Bachelor | 6 | 10% |
| Student > Ph. D. Student | 6 | 10% |
| Unspecified | 5 | 8% |
| Student > Master | 4 | 6% |
| Other | 6 | 10% |
| Unknown | 20 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 19% |
| Agricultural and Biological Sciences | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Unspecified | 5 | 8% |
| Psychology | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 21 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2018.
All research outputs
#6,488,468
of 24,217,893 outputs
Outputs from Brain Structure and Function
#462
of 1,725 outputs
Outputs of similar age
#101,411
of 334,935 outputs
Outputs of similar age from Brain Structure and Function
#8
of 54 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,725 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 334,935 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.