Title |
Amyotrophic Lateral Sclerosis Genetic Studies
|
---|---|
Published in |
The Neuroscientist, November 2014
|
DOI | 10.1177/1073858414555404 |
Pubmed ID | |
Authors |
Ji He, Marie Mangelsdorf, Dongsheng Fan, Perry Bartlett, Matthew A. Brown |
Abstract |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of obscure etiology. Multiple genetic studies have been conducted to advance our understanding of the disease, employing a variety of techniques such as linkage mapping in families, to genome-wide association studies and sequencing based approaches such as whole exome sequencing and whole genome sequencing and a few epigenetic analyses. While major progress has been made, the majority of the genetic variation involved in ALS is yet to be undefined. The optimal study designs to investigate ALS depend on the genetic model for the disease, and it is likely that different approaches will be required to map genes involved in familial and sporadic disease. The potential approaches and their strengths and weaknesses are discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Australia | 1 | 20% |
United States | 1 | 20% |
France | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Korea, Republic of | 1 | 1% |
United States | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 93 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 15 | 16% |
Student > Ph. D. Student | 14 | 15% |
Researcher | 11 | 11% |
Student > Bachelor | 11 | 11% |
Student > Doctoral Student | 7 | 7% |
Other | 15 | 16% |
Unknown | 23 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 18 | 19% |
Biochemistry, Genetics and Molecular Biology | 16 | 17% |
Medicine and Dentistry | 13 | 14% |
Agricultural and Biological Sciences | 13 | 14% |
Linguistics | 2 | 2% |
Other | 8 | 8% |
Unknown | 26 | 27% |