Title |
Human hepatic stellate cell isolation and characterization
|
---|---|
Published in |
Journal of Gastroenterology, November 2017
|
DOI | 10.1007/s00535-017-1404-4 |
Pubmed ID | |
Authors |
Linshan Shang, Mojgan Hosseini, Xiao Liu, Tatiana Kisseleva, David Allen Brenner |
Abstract |
The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic fibrosis. Significant understanding of HSCs has been achieved using rodent models and isolated murine HSCs; as well as investigating human liver tissues and human HSCs. There is growing interest and need of translating rodent study findings to human HSCs and human liver diseases. However, species-related differences impose challenges on the translational research. In this review, we focus on the current information on human HSCs isolation methods, human HSCs markers, and established human HSC cell lines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 206 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 32 | 16% |
Student > Ph. D. Student | 31 | 15% |
Student > Bachelor | 27 | 13% |
Student > Master | 26 | 13% |
Student > Doctoral Student | 9 | 4% |
Other | 20 | 10% |
Unknown | 61 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 56 | 27% |
Medicine and Dentistry | 24 | 12% |
Agricultural and Biological Sciences | 18 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 6% |
Engineering | 9 | 4% |
Other | 20 | 10% |
Unknown | 66 | 32% |