| Title |
Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort
|
|---|---|
| Published in |
Diabetologia, November 2017
|
| DOI | 10.1007/s00125-017-4489-7 |
| Pubmed ID | |
| Authors |
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi |
| Abstract |
Recent evidence suggests that oxidative stress may contribute to the pathogenesis of type 2 diabetes. The diet, and especially fruit and vegetables, contains a variety of compounds with antioxidant activity, which may have cumulative/synergistic antioxidant effects. The total antioxidant capacity, an index derived from dietary intake, is a single estimate of antioxidant capacity from all dietary antioxidants. The main aim of this study was to investigate the relationship between total antioxidant capacity and risk of type 2 diabetes. Among 64,223 women (mean age 52 ± 7 years) from the French E3N-European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 1751 women had validated type 2 diabetes during 15 years of follow-up. The total antioxidant capacity was estimated with the ferric ion-reducing antioxidant power (FRAP) method. Adjusted Cox proportional hazards regression models were used to calculate HRs and 95% CIs for the associations between total antioxidant capacity and type 2 diabetes risk, adjusted for potential confounders. In multivariable models, higher levels of total antioxidant capacity were associated with a lower risk of type 2 diabetes. Compared with women in the lowest quintile, women in the third, fourth and fifth quintiles for total antioxidant capacity had HRs of 0.74 (95% CI 0.63, 0.86), 0.70 (95% CI 0.59, 0.83) and 0.73 (95% CI 0.60, 0.89), respectively. The inverse association between total antioxidant capacity and risk of type 2 diabetes was linear up to values of 15 mmol/day, after which the effect reached a plateau. Our findings suggest that the total antioxidant capacity may play an important role in reducing the risk of type 2 diabetes in middle-aged women. More studies are warranted to better understand the biological mechanisms underlying this inverse association. |
X Demographics
The data shown below were collected from the profiles of 70 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 11 | 16% |
| United Kingdom | 8 | 11% |
| France | 6 | 9% |
| Canada | 5 | 7% |
| Germany | 2 | 3% |
| Curaçao | 1 | 1% |
| Argentina | 1 | 1% |
| Sweden | 1 | 1% |
| Japan | 1 | 1% |
| Other | 4 | 6% |
| Unknown | 30 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 40 | 57% |
| Practitioners (doctors, other healthcare professionals) | 20 | 29% |
| Scientists | 10 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 106 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 15% |
| Researcher | 13 | 12% |
| Student > Master | 13 | 12% |
| Student > Ph. D. Student | 8 | 8% |
| Student > Doctoral Student | 6 | 6% |
| Other | 18 | 17% |
| Unknown | 32 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 18 | 17% |
| Medicine and Dentistry | 18 | 17% |
| Agricultural and Biological Sciences | 10 | 9% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Sports and Recreations | 4 | 4% |
| Other | 11 | 10% |
| Unknown | 37 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 317. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#104,555
of 25,099,766 outputs
Outputs from Diabetologia
#73
of 5,316 outputs
Outputs of similar age
#2,237
of 337,916 outputs
Outputs of similar age from Diabetologia
#2
of 74 outputs
Altmetric has tracked 25,099,766 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,316 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 24.6. This one has done particularly well, scoring higher than 98% of its peers.
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We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.