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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Gastrointestinal Microbiome and Musculoskeletal Diseases: A Beneficial Role for Probiotics and Prebiotics
|
|---|---|
| Published in |
Pathogens, November 2013
|
| DOI | 10.3390/pathogens2040606 |
| Pubmed ID | |
| Authors |
Luis Vitetta, Samantha Coulson, Anthony W. Linnane, Henry Butt |
| Abstract |
Natural medicines are an attractive option for patients diagnosed with common and debilitating musculoskeletal diseases such as Osteoarthritis (OA) or Rheumatoid Arthritis (RA). The high rate of self-medication with natural products is due to (1) lack of an available cure and (2) serious adverse events associated with chronic use of pharmaceutical medications in particular non-steroidal anti-inflammatory drugs (NSAIDs) and high dose paracetamol. Pharmaceuticals to treat pain may disrupt gastrointestinal (GIT) barrier integrity inducing GIT inflammation and a state of and hyper-permeability. Probiotics and prebiotics may comprise plausible therapeutic options that can restore GIT barrier functionality and down regulate pro-inflammatory mediators by modulating the activity of, for example, Clostridia species known to induce pro-inflammatory mediators. The effect may comprise the rescue of gut barrier physiological function. A postulated requirement has been the abrogation of free radical formation by numerous natural antioxidant molecules in order to improve musculoskeletal health outcomes, this notion in our view, is in error. The production of reactive oxygen species (ROS) in different anatomical environments including the GIT by the epithelial lining and the commensal microbe cohort is a regulated process, leading to the formation of hydrogen peroxide which is now well recognized as an essential second messenger required for normal cellular homeostasis and physiological function. The GIT commensal profile that tolerates the host does so by regulating pro-inflammatory and anti-inflammatory GIT mucosal actions through the activity of ROS signaling thereby controlling the activity of pathogenic bacterial species. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 78% |
| Australia | 1 | 11% |
| Unknown | 1 | 11% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 78% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Italy | 1 | <1% |
| Australia | 1 | <1% |
| Ukraine | 1 | <1% |
| Denmark | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 154 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 15% |
| Student > Bachelor | 22 | 14% |
| Student > Ph. D. Student | 21 | 13% |
| Student > Master | 19 | 12% |
| Student > Doctoral Student | 11 | 7% |
| Other | 32 | 20% |
| Unknown | 31 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 27% |
| Agricultural and Biological Sciences | 34 | 21% |
| Nursing and Health Professions | 14 | 9% |
| Immunology and Microbiology | 8 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Other | 18 | 11% |
| Unknown | 37 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2023.
All research outputs
#1,341,945
of 24,584,609 outputs
Outputs from Pathogens
#118
of 4,559 outputs
Outputs of similar age
#12,258
of 218,273 outputs
Outputs of similar age from Pathogens
#1
of 6 outputs
Altmetric has tracked 24,584,609 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,559 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 218,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them