| Title |
The influence of age and mild cognitive impairment on associative memory performance and underlying brain networks
|
|---|---|
| Published in |
Brain Imaging and Behavior, November 2014
|
| DOI | 10.1007/s11682-014-9335-7 |
| Pubmed ID | |
| Authors |
Christiane S. H. Oedekoven, Andreas Jansen, James L. Keidel, Tilo Kircher, Dirk Leube |
| Abstract |
Associative memory is essential to everyday activities, such as the binding of faces and corresponding names to form single bits of information. However, this ability often becomes impaired with increasing age. The most important neural substrate of associative memory is the hippocampus, a structure crucially implicated in the pathogenesis of Alzheimer's disease (AD). The main aim of this study was to compare neural correlates of associative memory in healthy aging and mild cognitive impairment (MCI), an at-risk state for AD. We used fMRI to investigate differences in brain activation and connectivity between young controls (n = 20), elderly controls (n = 32) and MCI patients (n = 21) during associative memory retrieval. We observed lower hippocampal activation in MCI patients than control groups during a face-name recognition task, and the magnitude of this decrement was correlated with lower associative memory performance. Further, increased activation in precentral regions in all older adults indicated a stronger involvement of the task positive network (TPN) with age. Finally, functional connectivity analysis revealed a stronger link of hippocampal and striatal components in older adults in comparison to young controls, regardless of memory impairment. In elderly controls, this went hand-in-hand with a stronger activation of striatal areas. Increased TPN activation may be linked to greater reliance on cognitive control in both older groups, while increased functional connectivity between the hippocampus and the striatum may suggest dedifferentiation, especially in elderly controls. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 96 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 25% |
| Student > Doctoral Student | 12 | 12% |
| Student > Master | 12 | 12% |
| Researcher | 12 | 12% |
| Student > Bachelor | 7 | 7% |
| Other | 11 | 11% |
| Unknown | 22 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 35 | 35% |
| Neuroscience | 15 | 15% |
| Medicine and Dentistry | 9 | 9% |
| Nursing and Health Professions | 4 | 4% |
| Engineering | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 29 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2016.
All research outputs
#15,310,081
of 22,770,070 outputs
Outputs from Brain Imaging and Behavior
#671
of 1,154 outputs
Outputs of similar age
#153,124
of 262,656 outputs
Outputs of similar age from Brain Imaging and Behavior
#15
of 21 outputs
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