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Mendeley readers
Attention Score in Context
| Title |
Identification of a membrane-associated interleukin 1 in macrophages.
|
|---|---|
| Published in |
Proceedings of the National Academy of Sciences of the United States of America, February 1985
|
| DOI | 10.1073/pnas.82.4.1204 |
| Pubmed ID | |
| Authors |
E A Kurt-Jones, D I Beller, S B Mizel, E R Unanue |
| Abstract |
We have found a surface membrane-associated interleukin 1 (IL-1) with potent thymocyte and T-cell stimulatory activity on peptone-elicited peritoneal macrophages. The IL-1 activity was demonstrated on both fixed macrophage monolayers and on isolated membranes from unfixed macrophages. Membrane IL-1 was induced by adherence and/or by adding heat-killed Listeria monocytogenes to macrophage cultures. The macrophage membrane IL-1 was similar functionally and antigenically to soluble IL-1, but its expression could be temporally dissociated from IL-1 secretion; membrane IL-1 was induced earlier and persisted longer than IL-1 secretion during in vitro macrophage culture. Moreover, when cultured macrophages that had ceased both secretion and membrane expression of IL-1 were restimulated by adding heat-killed Listeria, substantial membrane IL-1 was induced in the absence of detectable IL-1 secretion. Membrane IL-1 appears to be an integral membrane protein since it was solubilized by detergent but was not eluted by EDTA, high salt, or low pH treatment of the membranes. |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Singapore | 1 | 1% |
| Vietnam | 1 | 1% |
| Unknown | 88 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 27% |
| Researcher | 15 | 16% |
| Student > Doctoral Student | 13 | 14% |
| Student > Master | 6 | 7% |
| Other | 4 | 4% |
| Other | 7 | 8% |
| Unknown | 21 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 36% |
| Immunology and Microbiology | 13 | 14% |
| Medicine and Dentistry | 11 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 10% |
| Veterinary Science and Veterinary Medicine | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 22 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 October 2023.
All research outputs
#3,660,693
of 24,727,020 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#36,779
of 101,698 outputs
Outputs of similar age
#1,334
of 39,168 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#20
of 163 outputs
Altmetric has tracked 24,727,020 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,698 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 39,168 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 163 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.