Title |
Interethnic Differences in Pharmacokinetics of Antibacterials
|
---|---|
Published in |
Clinical Pharmacokinetics, November 2014
|
DOI | 10.1007/s40262-014-0209-3 |
Pubmed ID | |
Authors |
Danny Tsai, Janattul-Ain Jamal, Joshua S. Davis, Jeffrey Lipman, Jason A. Roberts |
Abstract |
Optimal antibacterial dosing is imperative for maximising clinical outcome. Many factors can contribute to changes in the pharmacokinetics of antibacterials to the extent where dose adjustment may be needed. In acute illness, substantial changes in important pharmacokinetic parameters such as volume of distribution and clearance can occur for certain antibacterials. The possibility of interethnic pharmacokinetic differences can further complicate attempts to design an appropriate dosing regimen. Factors of ethnicity, such as genetics, body size and fat distribution, contribute to differences in absorption, distribution, metabolism and elimination of drugs. Despite extensive previous work on the altered pharmacokinetics of antibacterials in some patient groups such as the critically ill, knowledge of interethnic pharmacokinetic differences for antibacterials is limited. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 20% |
Canada | 1 | 20% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 1 | 2% |
Unknown | 50 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 16% |
Other | 6 | 12% |
Researcher | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Student > Doctoral Student | 3 | 6% |
Other | 10 | 20% |
Unknown | 14 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 20% |
Medicine and Dentistry | 7 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Nursing and Health Professions | 4 | 8% |
Business, Management and Accounting | 2 | 4% |
Other | 8 | 16% |
Unknown | 16 | 31% |