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Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa

Overview of attention for article published in NeuroImage: Clinical, April 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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1 blog
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Title
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa
Published in
NeuroImage: Clinical, April 2014
DOI 10.1016/j.nicl.2014.04.002
Pubmed ID
Authors

Stephanie Kullmann, Katrin E. Giel, Martin Teufel, Ansgar Thiel, Stephan Zipfel, Hubert Preissl

Abstract

Neuroimaging studies investigating the neural profile of anorexia nervosa (AN) have revealed a predominant imbalance between the reward and inhibition systems of the brain, which are also hallmark characteristics of the disorder. However, little is known whether these changes can also be determined independent of task condition, using resting-state functional magnetic resonance imaging, in currently ill AN patients. Therefore the aim of our study was to investigate resting-state connectivity in AN patients (n = 12) compared to healthy athlete (n = 12) and non-athlete (n = 14) controls. For this purpose, we used degree centrality to investigate functional connectivity of the whole-brain network and then Granger causality to analyze effective connectivity (EC), to understand directional aspects of potential alterations. We were able to show that the bilateral inferior frontal gyrus (IFG) is a region of special functional importance within the whole-brain network, in AN patients, revealing reduced functional connectivity compared to both healthy control groups. Furthermore, we found decreased EC from the right IFG to the midcingulum and increased EC from the bilateral orbitofrontal gyrus to the right IFG. For the left IFG, we only observed increased EC from the bilateral insula to the left IFG. These results suggest that AN patients have reduced connectivity within the cognitive control system of the brain and increased connectivity within regions important for salience processing. Due to its fundamental role in inhibitory behavior, including motor response, altered integrity of the inferior frontal cortex could contribute to hyperactivity in AN.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Switzerland 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Spain 1 <1%
Unknown 140 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 18%
Student > Bachelor 20 14%
Student > Master 18 12%
Student > Doctoral Student 17 12%
Researcher 17 12%
Other 23 16%
Unknown 25 17%
Readers by discipline Count As %
Psychology 41 28%
Medicine and Dentistry 25 17%
Neuroscience 19 13%
Agricultural and Biological Sciences 6 4%
Engineering 4 3%
Other 14 10%
Unknown 37 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2014.
All research outputs
#4,150,974
of 25,374,917 outputs
Outputs from NeuroImage: Clinical
#725
of 2,802 outputs
Outputs of similar age
#39,061
of 239,966 outputs
Outputs of similar age from NeuroImage: Clinical
#7
of 28 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,802 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,966 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.