| Title |
T2*-based MR imaging (gradient echo or susceptibility-weighted imaging) in midline and off-midline intracranial germ cell tumors: a pilot study
|
|---|---|
| Published in |
Neuroradiology, November 2017
|
| DOI | 10.1007/s00234-017-1947-3 |
| Pubmed ID | |
| Authors |
Giovanni Morana, Cesar Augusto Alves, Domenico Tortora, Jonathan L. Finlay, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Marco Pavanello, Claudia Milanaccio, Mohamad Maghnie, Andrea Rossi, Maria Luisa Garrè |
| Abstract |
The role of T2*-based MR imaging in intracranial germ cell tumors (GCTs) has not been fully elucidated. The aim of this study was to evaluate the susceptibility-weighted imaging (SWI) or T2* gradient echo (GRE) features of germinomas and non-germinomatous germ cell tumors (NGGCTs) in midline and off-midline locations. We retrospectively evaluated all consecutive pediatric patients referred to our institution between 2005 and 2016, for newly diagnosed, treatment-naïve intracranial GCT, who underwent MRI, including T2*-based MR imaging (T2* GRE sequences or SWI). Standard pre- and post-contrast T1- and T2-weighted imaging characteristics along with T2*-based MR imaging features of all lesions were evaluated. Diagnosis was performed in accordance with the SIOP CNS GCT protocol criteria. Twenty-four subjects met the inclusion criteria (17 males and 7 females). There were 17 patients with germinomas, including 5 basal ganglia primaries, and 7 patients with secreting NGGCT. All off-midline germinomas presented with SWI or GRE hypointensity; among midline GCT, all NGGCTs showed SWI or GRE hypointensity whereas all but one pure germinoma were isointense or hyperintense to normal parenchyma. A significant difference emerged on T2*-based MR imaging among midline germinomas, NGGCTs, and off-midline germinomas (p < 0.001). Assessment of the SWI or GRE characteristics of intracranial GCT may potentially assist in differentiating pure germinomas from NGGCT and in the characterization of basal ganglia involvement. T2*-based MR imaging is recommended in case of suspected intracranial GCT. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 13% |
| Student > Postgraduate | 3 | 13% |
| Librarian | 1 | 4% |
| Unspecified | 1 | 4% |
| Student > Master | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 11 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 13% |
| Neuroscience | 3 | 13% |
| Nursing and Health Professions | 1 | 4% |
| Unspecified | 1 | 4% |
| Computer Science | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 14 | 61% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2018.
All research outputs
#17,919,786
of 23,007,887 outputs
Outputs from Neuroradiology
#844
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Outputs of similar age
#233,856
of 326,836 outputs
Outputs of similar age from Neuroradiology
#9
of 23 outputs
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