| Title |
Glycosaminoglycans from fish swim bladder: isolation, structural characterization and bioactive potential
|
|---|---|
| Published in |
Glycoconjugate Journal, November 2017
|
| DOI | 10.1007/s10719-017-9804-5 |
| Pubmed ID | |
| Authors |
Yongxi Pan, Peipei Wang, Fuming Zhang, Yanlei Yu, Xing Zhang, Lei Lin, Robert J. Linhardt |
| Abstract |
The swim bladder of fish is an internal gas-filled organ that allows fish to control their buoyancy and swimming depth. Fish maws (the dried swim bladders of fish) have been used over many centuries as traditional medicines, tonics and a luxurious gourmet food in China and Southeast Asia. Little is known about the structural information of polysaccharides comprising this important functional material of fish tissue. In the present study, the total glycosaminoglycan (GAG) from fish maw was characterized. Two GAGs were identified, chondroitin sulfate (CS, having a molecular weight of 18-40 kDa) and heparan sulfate (HS), corresponding to 95% and 5% of the total GAG, respectively. Chondroitinase digestion showed that the major CS GAG was composed of ΔUA-1 → 3-GalNAc4S (59.7%), ΔUA-1 → 3-GalNAc4,6S (36.5%), ΔUA-1 → 3-GalNAc6S (2.2%) and ΔUA-1 → 3-GalNAc (1.6%) disaccharide units. (1)H-NMR analysis and degradation with specific chondroitinases, both CS-type A/C and CS-type B were present in a ratio of 1.4:1. Analysis using surface plasmon resonance showed that fibroblast growth factor (FGF)-2 bound to the CS fraction (KD = 136 nM). These results suggest that this CS may be involved in FGF-signal pathway, mediating tissue repair, regeneration and wound healing. The CS, as the major GAG in fish maw, may have potential pharmacological activity in accelerating wound healing. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 27% |
| Student > Master | 4 | 12% |
| Student > Bachelor | 3 | 9% |
| Student > Doctoral Student | 1 | 3% |
| Librarian | 1 | 3% |
| Other | 4 | 12% |
| Unknown | 11 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 24% |
| Biochemistry, Genetics and Molecular Biology | 4 | 12% |
| Social Sciences | 2 | 6% |
| Chemistry | 2 | 6% |
| Chemical Engineering | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 13 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2017.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Glycoconjugate Journal
#800
of 929 outputs
Outputs of similar age
#263,234
of 339,332 outputs
Outputs of similar age from Glycoconjugate Journal
#2
of 7 outputs
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