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Parvovirus B19 in HIV+ adult patients with different CD4+ lymphocyte counts

Overview of attention for article published in Journal of Medical Microbiology, November 2017
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Title
Parvovirus B19 in HIV+ adult patients with different CD4+ lymphocyte counts
Published in
Journal of Medical Microbiology, November 2017
DOI 10.1099/jmm.0.000629
Pubmed ID
Authors

Mauro Sebastian Pedranti, Gonzalo Rodriguez-Lombardi, Romina Bracciaforte, Natalia Romano, Pablo Lujan, Brenda Ricchi, Jorge Mautino, Maria Pilar Adamo

Abstract

Human parvovirus B19 (B19V) can cause anemia in immunocompromised patients. We aimed to investigate the presence of B19V in HIV+ adults with different CD4+ T cell counts, to recognise the frequency of B19V in these different conditions and its possible association with anemia. We studied B19V specific IgM, IgG and DNA in 98 HIV+ patients and in 52 healthy individuals. HIV load, CD4+ counts and haemoglobin level were also determined in the patients. No individual in the control group had detectable IgM, 41/52 (78.8 %) had IgG and 5/52 (9.6 %) had B19V DNA. Among HIV+ patients, we found 5/98 (5.1 %) IgM+, 66/98 (67.3 %) IgG+ and 15/98 (15.3 %) had B19V DNA (no significant differences between the two groups compared). Considering the CD4+ cell range in HIV patients, 37 had <200 CD4+ cells ml(-1), 31 had 200-500, and 30 had >500. Anti-B19V IgG prevalence in patients with >500 CD4+ cells ml(-1) was significantly higher than in the rest (P=0.004) and compared to the control (P=0.046). B19V DNA concentration was always <10(3) IU ml(-1), including 5 healthy individuals and 15 HIV+ patients. There was no significant association between B19V IgM or DNA and anemia nor between B19V DNA and HIV load. The results indicate that B19V is not a high-risk factor for anemia in adult HIV+ patients under HAART treatment. Further studies will contribute to elucidate the mechanisms and significance of B19V DNA prevalence/persistence in adults, independently of the CD4+ cell status.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 23%
Other 2 15%
Librarian 1 8%
Student > Bachelor 1 8%
Student > Ph. D. Student 1 8%
Other 3 23%
Unknown 2 15%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Agricultural and Biological Sciences 2 15%
Biochemistry, Genetics and Molecular Biology 1 8%
Arts and Humanities 1 8%
Immunology and Microbiology 1 8%
Other 1 8%
Unknown 3 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2017.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Journal of Medical Microbiology
#2,175
of 2,960 outputs
Outputs of similar age
#217,904
of 340,903 outputs
Outputs of similar age from Journal of Medical Microbiology
#21
of 43 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,960 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,903 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.