Title |
The regulation effect of AMPK in immune related diseases
|
---|---|
Published in |
Science China Life Sciences, November 2017
|
DOI | 10.1007/s11427-017-9169-6 |
Pubmed ID | |
Authors |
Jing Wang, Zhenyu Li, Li Gao, Yanshuang Qi, Haibo Zhu, Xuemei Qin |
Abstract |
AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a key role in energetic metabolism regulation. Metabolic changes in immune cells, such as dendritic cell (DC), macrophages, neutrophils and lymphocytes that participate in the signal directed programs that promote or inhibit immune mediated diseases, including cancer, atherosclerosis and inflammatory diseases. Multiple pathogenic mechanisms are involved in the initiation and progression of disease, and many pathways have been uncovered. The mechanistic overlap in the metabolic changes and inflammation could indicate that some of the targets they have are in common, whereas AMPK could be useful in treatment of both disorders. The insight into identification of AMPK responsible for specific immune regulation, anti-inflammatory actions and understanding of the underlying molecular mechanism will promote the generation of novel AMPK activators, and provide novel therapy strategy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 16% |
Student > Bachelor | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Student > Doctoral Student | 1 | 5% |
Researcher | 1 | 5% |
Other | 1 | 5% |
Unknown | 9 | 47% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 3 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Immunology and Microbiology | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Other | 0 | 0% |
Unknown | 10 | 53% |