Title |
Safety and immunogenicity of dry powder measles vaccine administered by inhalation: A randomized controlled Phase I clinical trial
|
---|---|
Published in |
Vaccine, October 2014
|
DOI | 10.1016/j.vaccine.2014.09.071 |
Pubmed ID | |
Authors |
Stephen Cape, Amol Chaudhari, Vivek Vaidya, Ravindra Mulay, Shalaka Agarkhedkar, Charles Shermer, Marcus Collins, Raydel Anderson, Sharad Agarkhedkar, Prasad S Kulkarni, Scott Winston, Robert Sievers, Rajeev M Dhere, Bhagwat Gunale, Ken Powell, Paul A Rota, Mark Papania |
Abstract |
Measles is a highly infectious respiratory disease which causes 122,000 deaths annually. Although measles vaccine is extremely safe and effective, vaccine coverage could be improved by a vaccine that is more easily administered and transported. We developed an inhalable dry powder measles vaccine (MVDP) and two delivery devices, and demonstrated safety, immunogenicity, and efficacy of the vaccine in preclinical studies. Here we report the first clinical trial of MVDP delivered by inhalation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 60% |
Singapore | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 1% |
Unknown | 77 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 13% |
Student > Ph. D. Student | 9 | 12% |
Student > Master | 8 | 10% |
Student > Doctoral Student | 5 | 6% |
Student > Bachelor | 5 | 6% |
Other | 14 | 18% |
Unknown | 27 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 26% |
Agricultural and Biological Sciences | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Immunology and Microbiology | 3 | 4% |
Engineering | 2 | 3% |
Other | 12 | 15% |
Unknown | 30 | 38% |