Title |
MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma
|
---|---|
Published in |
Journal of Neuro-Oncology, November 2014
|
DOI | 10.1007/s11060-014-1656-2 |
Pubmed ID | |
Authors |
Shoudan Zhang, Qigui Qi |
Abstract |
Glioblastomas (GBMs) are the highest grade of primary brain tumors with astrocytic similarity and are characterized dispersal of tumor cell. Metastasis suppressor 1 (MTSS1) play an important role in cancer metastasis. Recent studies indicating that MTSS1 as a potential tumor suppressor and its reduced expression associated with poor prognosis in many cancer types. However, the relationship with the prognosis of patients and the molecular mechanism of MTSS1 renders a tumor suppressor effect in GBM is unknown. Here, we showed that low MTSS1 gene expression is associated with poor outcomes in patients with GBM. Overexpression of MTSS1 in U-87 MG cells exhibited inhibited glioma cell growth, colony formation, migration and invasion. Mechanistically, we found that high MTSS1 expression in U-87 MG reduced expression of CTTN. These results implicate that the role of MTSS1 suppresses cell migration and invasion by inhibiting expression of CTTN and as a prognosis biomarker in GBM. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 5% |
Brazil | 1 | 5% |
Unknown | 20 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 23% |
Researcher | 3 | 14% |
Other | 2 | 9% |
Student > Doctoral Student | 2 | 9% |
Student > Bachelor | 2 | 9% |
Other | 4 | 18% |
Unknown | 4 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 5 | 23% |
Medicine and Dentistry | 5 | 23% |
Agricultural and Biological Sciences | 4 | 18% |
Unspecified | 1 | 5% |
Social Sciences | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 23% |