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Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis

Overview of attention for article published in Cell Stem Cell, November 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

blogs
1 blog
twitter
28 X users
weibo
2 weibo users
facebook
5 Facebook pages

Citations

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167 Dimensions

Readers on

mendeley
233 Mendeley
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Title
Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis
Published in
Cell Stem Cell, November 2014
DOI 10.1016/j.stem.2014.10.019
Pubmed ID
Authors

Michael S. Kareta, Laura L. Gorges, Sana Hafeez, Bérénice A. Benayoun, Samuele Marro, Anne-Flore Zmoos, Matthew J. Cecchini, Damek Spacek, Luis F.Z. Batista, Megan O’Brien, Yi-Han Ng, Cheen Euong Ang, Dedeepya Vaka, Steven E. Artandi, Frederick A. Dick, Anne Brunet, Julien Sage, Marius Wernig

Abstract

Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells to a pluripotent state. Unexpectedly, this effect is cell cycle independent, and instead reflects direct binding of Rb to pluripotency genes, including Sox2 and Oct4, which leads to a repressed chromatin state. More broadly, this regulation of pluripotency networks and Sox2 in particular is critical for the initiation of tumors upon loss of Rb in mice. These studies therefore identify Rb as a global transcriptional repressor of pluripotency networks, providing a molecular basis for previous reports about its involvement in cell fate pliability, and implicate misregulation of pluripotency factors such as Sox2 in tumorigenesis related to loss of Rb function.

X Demographics

X Demographics

The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 233 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 <1%
United States 2 <1%
Japan 2 <1%
United Kingdom 1 <1%
Portugal 1 <1%
France 1 <1%
Korea, Republic of 1 <1%
Unknown 223 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 66 28%
Researcher 47 20%
Student > Master 30 13%
Student > Bachelor 13 6%
Professor > Associate Professor 12 5%
Other 33 14%
Unknown 32 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 82 35%
Agricultural and Biological Sciences 72 31%
Medicine and Dentistry 26 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Immunology and Microbiology 3 1%
Other 14 6%
Unknown 32 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2018.
All research outputs
#1,393,614
of 25,394,764 outputs
Outputs from Cell Stem Cell
#914
of 2,823 outputs
Outputs of similar age
#15,667
of 270,464 outputs
Outputs of similar age from Cell Stem Cell
#18
of 48 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,823 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 48.5. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,464 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.