| Title |
A tale of two methane monooxygenases
|
|---|---|
| Published in |
JBIC Journal of Biological Inorganic Chemistry, November 2016
|
| DOI | 10.1007/s00775-016-1419-y |
| Pubmed ID | |
| Authors |
Matthew O. Ross, Amy C. Rosenzweig |
| Abstract |
Methane monooxygenase (MMO) enzymes activate O2 for oxidation of methane. Two distinct MMOs exist in nature, a soluble form that uses a diiron active site (sMMO) and a membrane-bound form with a catalytic copper center (pMMO). Understanding the reaction mechanisms of these enzymes is of fundamental importance to biologists and chemists, and is also relevant to the development of new biocatalysts. The sMMO catalytic cycle has been elucidated in detail, including O2 activation intermediates and the nature of the methane-oxidizing species. By contrast, many aspects of pMMO catalysis remain unclear, most notably the nuclearity and molecular details of the copper active site. Here, we review the current state of knowledge for both enzymes, and consider pMMO O2 activation intermediates suggested by computational and synthetic studies in the context of existing biochemical data. Further work is needed on all fronts, with the ultimate goal of understanding how these two remarkable enzymes catalyze a reaction not readily achieved by any other metalloenzyme or biomimetic compound. |
Mendeley readers
The data shown below were compiled from readership statistics for 352 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | <1% |
| Unknown | 350 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 94 | 27% |
| Student > Bachelor | 42 | 12% |
| Researcher | 35 | 10% |
| Student > Master | 29 | 8% |
| Student > Doctoral Student | 27 | 8% |
| Other | 26 | 7% |
| Unknown | 99 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 97 | 28% |
| Biochemistry, Genetics and Molecular Biology | 61 | 17% |
| Agricultural and Biological Sciences | 22 | 6% |
| Engineering | 19 | 5% |
| Chemical Engineering | 14 | 4% |
| Other | 33 | 9% |
| Unknown | 106 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2023.
All research outputs
#4,981,964
of 23,842,189 outputs
Outputs from JBIC Journal of Biological Inorganic Chemistry
#85
of 664 outputs
Outputs of similar age
#95,292
of 419,914 outputs
Outputs of similar age from JBIC Journal of Biological Inorganic Chemistry
#2
of 12 outputs
Altmetric has tracked 23,842,189 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 664 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 419,914 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.