| Title |
Predictors of adverse psychological experiences surrounding genome-wide profiling for disease risk
|
|---|---|
| Published in |
Journal of Community Genetics, November 2017
|
| DOI | 10.1007/s12687-017-0339-z |
| Pubmed ID | |
| Authors |
K. M. Broady, K. E. Ormond, E. J. Topol, N. J. Schork, Cinnamon S. Bloss |
| Abstract |
This study aimed to identify predictors of adverse psychological experiences among direct-to-consumer (DTC) genomic test consumers. We performed a secondary analysis on data from the Scripps Genomic Health Initiative (SGHI), which studied 2037 individuals tested with commercially available tests yielding personalized risk estimates for 23 common, genetically complex diseases. As part of the original study, the participants completed baseline and follow-up survey measures assessing demographics, personal and family health history, attitudes toward genetic testing, anxiety (State-Trait Anxiety Inventory (STAI)), test-related distress (Impact of Event Scale-Revised (IES-R)), and reactions to receipt of results. To further describe the participants who had an adverse psychological outcome, this secondary analysis defined two different variables ("distress response" and "psychologically sensitive participants") and examined their relationship to various demographic variables and other survey responses. One hundred thirty participants (6.4%) were defined as having a "distress response" to receipt of results based on changes in STAI and/or IES. Four hundred thirty-one participants (21.2%) were defined as being "psychologically sensitive" based on high STAI scores both pre- and post-receipt of results. For psychologically sensitive subjects, younger age emerged as a predictor (p < 0.0005). Family history and personal history were only significant predictors for Alzheimer's disease in the psychologically sensitive participants (p = .03) and restless leg syndrome in those with a distress response (p = .03). Psychologically sensitive participants were more likely to indicate a number of pre-test concerns than were controls, but neither group of participants were any more likely to follow up with their physician or a free genetic counseling service after the return of results. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 22% |
| Student > Bachelor | 9 | 17% |
| Researcher | 9 | 17% |
| Student > Ph. D. Student | 4 | 7% |
| Student > Postgraduate | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 13 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 24% |
| Medicine and Dentistry | 7 | 13% |
| Social Sciences | 4 | 7% |
| Nursing and Health Professions | 3 | 6% |
| Psychology | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 16 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2019.
All research outputs
#1,748,441
of 23,007,887 outputs
Outputs from Journal of Community Genetics
#27
of 369 outputs
Outputs of similar age
#36,912
of 326,002 outputs
Outputs of similar age from Journal of Community Genetics
#2
of 15 outputs
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So far Altmetric has tracked 369 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done particularly well, scoring higher than 92% of its peers.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.